ArticleAntimicrobial agents and chemotherapy2003
Interlaboratory comparison of agar dilution and Etest methods for determining the MICs of antibiotics used in management of Neisseria meningitidis infections.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
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- Susceptibilities of invasiveJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- Antibiotic susceptibility and molecular analysis of invasive Neisseria meningitidis recovered in the Republic of Ireland, 1996 to 2016.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco.Journal of clinical microbiology · 2018Article
- Use of Animal Models To Support Revising Meningococcal Breakpoints of β-Lactams.Antimicrobial agents and chemotherapy · 2016Article
- A cluster of invasive meningococcal disease revealed by the characterization of a novel serogroup B meningococcal clone.Epidemiology and infection · 2016Article
- Genetic diversity and levels of expression of factor H binding protein among carriage isolates of Neisseria meningitidis.PloS one · 2014Article
- Phenotypic and genotypic characteristics of Neisseria meningitidis disease-causing strains in Argentina, 2010.PloS one · 2013Article
- Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review.Microbiology (Reading, England) · 2011Review
- Multicenter study for defining the breakpoint for rifampin resistance in Neisseria meningitidis by rpoB sequencing.Antimicrobial agents and chemotherapy · 2010Article
- Comparative in vitro activity of Meropenem, Imipenem and Piperacillin/tazobactam against 1071 clinical isolates using 2 different methods: a French multicentre study.BMC infectious diseases · 2010Article
- Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives.Antimicrobial agents and chemotherapy · 2009Article
- Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005.Journal of clinical microbiology · 2008Article
- Combined real-time PCR and pyrosequencing strategy for objective, sensitive, specific, and high-throughput identification of reduced susceptibility to penicillins in Neisseria meningitidis.Antimicrobial agents and chemotherapy · 2008Article
- Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis.Antimicrobial agents and chemotherapy · 2007Article
- Total variation in the penA gene of Neisseria meningitidis: correlation between susceptibility to beta-lactam antibiotics and penA gene heterogeneity.Antimicrobial agents and chemotherapy · 2006Article
- Multilaboratory evaluation of disk diffusion antimicrobial susceptibility testing of Neisseria meningitidis isolates.Journal of clinical microbiology · 2006Article
- Interlaboratory comparison of PCR-based methods for detection of penicillin G susceptibility in Neisseria meningitidis.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that there is considerable variation in the methods and media used to determine the susceptibility of Neisseria meningitidis to antimicrobial agents in different countries. In this study, national and regional reference laboratories used a standardized methodology to determine the MICs of antibiotics used in the management of meningococcal infection. Fourteen laboratories participated in the study, determining the susceptibility to penicillin G, rifampin, cefotaxime, ceftriaxone, ciprofloxacin, and ofloxacin of a collection of 17 meningococci, of which 11 strains were previously defined as having intermediate resistance to penicillin (Pen(I)) by sequencing and restriction fragment length polymorphism analysis of the penA gene. The MIC was determined by agar dilution and Etest with Mueller-Hinton agar (MH), MH supplemented with sheep blood (MH+B), and MH supplemented with heated (chocolated) blood. Several laboratories encountered problems obtaining confluent growth with unsupplemented MH. MH+B was considered to give the most congruent and reproducible results among the study laboratories. The modal MIC for MH+B for each antibiotic and method was calculated to define the MIC consensus, allowing assessment of each individual laboratory's data in relation to the others. The agreement in each antibiotic/method/medium combination was defined as the percentage of laboratories with a result within one dilution of the modal result. For the whole study, an agreement of 90.6% was observed between agar dilution and Etest methods. The agreement in each laboratory/antibiotic/method combination ranged from 98.2% to 69.7%, with six laboratories demonstrating agreement higher than 90% and 11 more than 80%. The ability of the laboratories to detect the Pen(I) isolates ranged from 18.2% to 100%. The apparent difficulty in interpreting susceptibility to rifampin, particularly with the Etest method, is very interesting.
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