ReviewThe Iowa orthopaedic journal2003
Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas.
Review in The Iowa orthopaedic journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Popliteal artery pseudoaneurysm and secondary ipsilateral deep vein thrombosis caused by an exostosis in a mature adult.Journal of vascular surgery cases and innovative techniques · 2024Article
- Osteochondroma of the Distal Volar Thumb.Eplasty · 2019Article
- Development of the long bones in the hands and feet of children: radiographic and MR imaging correlation.Pediatric radiology · 2016Review
- Thrombosed Popliteal Artery Pseudoaneurysm as Herald of Tibial Osteochondroma.EJVES short reports · 2016Article
- Unusual solid mass in the popliteal fossa.BMJ case reports · 2013Article
- Intraoperative rupture of popliteal artery pseudoaneurysm secondary to distal femur osteochondroma: case report and review of the literature.The Pan African medical journal · 2013Review
- Hereditary multiple exostoses in the hands and fingers: early presentation and early surgical treatment in family members. Case reports.Hand (New York, N.Y.) · 2011Article
- Anatomical variation of co-existence of 4th and 5th short metacarpal bones, sesamoid ossicles and exostoses of ulna and radius in the same hand: a case report.Cases journal · 2008Article
- The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway.PLoS genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The osteochondroma is a common, benign, primary tumor of bone. A mechanism for its pathogenesis has not been identified, but loss of function of EXT genes is implicated in sporadic and hereditary multiple osteochondromas. Recent advances in the understanding of other molecular signaling pathways in the physis cast doubt on the latest pathogenetic theories. These advances are reviewed and used as the basis for a revised theory for pathogenesis: A clone of proliferating chondrocytes without functional EXT1 (or EXT2) expression fails to produce heparan sulfate; lack of heparan sulfate at the cell surface disrupts fibroblast growth factor signaling and Indian hedgehog diffusion, leading to focal overproliferation and adjacent bone collar deficiency, respectively; together these effects are proposed to contribute to osteochondroma pathogenesis.
Indexed as
Identifiers
14575257PMC1888388W1603488144What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.