ArticleParasitology research2003
Analysis of the genes expressed in Clonorchis sinensis adults using the expressed sequence tag approach.
Article in Parasitology research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Trematode Genomics and Proteomics.Advances in experimental medicine and biology · 2024Article
- An EF-handed Ca(2+)-binding protein of Chinese liver fluke Clonorchis sinensis.Parasitology research · 2013Article
- Transcriptome profiling of the fifth-stage larvae of Angiostrongylus cantonensis by next-generation sequencing.Parasitology research · 2013Article
- Citrate synthase from the liver fluke Fasciola hepatica.Parasitology research · 2013Article
- Identification and characterization of myophilin-like protein: a life stage and tissue-specific antigen of Clonorchis sinensis.Parasitology research · 2012Article
- Molecular characterization of Clonorchis sinensis tetraspanin 2 extracellular loop 2.Parasitology research · 2012Article
- Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis.PLoS neglected tropical diseases · 2011Article
- Expressed sequence tags from Eimeria brunetti--preliminary analysis and functional annotation.Parasitology research · 2011Article
- A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications.PLoS neglected tropical diseases · 2011Article
- Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini.PLoS neglected tropical diseases · 2010Article
- Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica.BMC genomics · 2010Article
- Functional genes and proteins of Clonorchis sinensis.The Korean journal of parasitology · 2009Review
- Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Gene expression profile of Clonorchis sinensis metacercariae.Parasitology research · 2008Article
- Clonorchis sinensis: molecular cloning and functional expression of a novel cytosolic glutathione transferase.Parasitology research · 2007Article
- Expressed sequence tag analysis of adult Clonorchis sinensis, the Chinese liver fluke.Parasitology research · 2006Article
- Molecular cloning and characterization of cDNA encoding a novel cytosolic glutathione transferase from Clonorchis sinensis.Parasitology research · 2006Article
- Expression and cross-species reactivity of fatty acid-binding protein of Clonorchis sinensis.Parasitology research · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clonorchis sinensis is a biliary tract parasite, which infects over 30 million people in China, Korea and Southeast Asia through the ingestion of undercooked freshwater fish that harbour the infective metacercariae. The genes expressed in C. sinensis adults were identified in order to develop novel drugs, better diagnostics and vaccines for the parasite. The C. sinensis cDNA library was constructed and DNA sequencing was performed with 450 randomly selected clones. Four hundred and fifteen clones contained the amino-acid-encoding sequences. The functions of these genes could be assigned by DNA sequence homology. Basic Local Alignment Search Tool X analysis showed that 277 of the 415 clones were strongly matched ( P<10(-9)) to previously identified proteins, while the remaining 138 fell into the "no database match" category. Among the clones matching previously identified proteins, 220 putatively identified genes were sorted into seven functional categories. These included the genes associated with energy metabolism (38), gene expression/RNA metabolism (21), regulatory/signalling components (14), protein metabolism/sorting (98), the structure/cytoskeleton (29), membrane transporters (ten) and antigenic proteins (ten). The remaining 57 clones were not included in these categories. The dataset included the genes encoding the proteases, a lipid binding protein, the antigen proteins and the other genes of interest from a diagnostics, drug or vaccine development viewpoint. The present expressed sequence tag analysis proved to be an effective tool for examining gene expression and identified several important genes which increase and complement our knowledge of the biology of C. sinensis.
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