ArticleInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity2003
Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects.
Article in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity.Journal of diabetes research · 2019Pooled it
- Trial
- A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion.International journal of obesity (2005) · 2006Trial
- Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children.The Journal of pediatrics · 2006Trial
- Article
- Reduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans.The Journal of clinical endocrinology and metabolism · 2020Article
- Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating.Journal of endocrinological investigation · 2019Article
- Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women's Study.The Journal of clinical endocrinology and metabolism · 2019Article
- The GLP-1 response to glucose does not mediate beta and alpha cell dysfunction in Hispanics with abnormal glucose metabolism.Diabetes research and clinical practice · 2018Article
- A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Differences in β-cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role?Pediatric diabetes · 2017Article
- Racial/Ethnic Differences in Insulin Resistance and Beta Cell Function: Relationship to Racial Disparities in Type 2 Diabetes among African Americans versus Caucasians.Current obesity reports · 2015Review
- The dipeptidyl peptidase (DPP)-4 inhibitors for type 2 diabetes mellitus in challenging patient groups.Advances in therapy · 2013Review
- Clinical characteristics of the responders to dipeptidyl peptidase-4 inhibitors in Korean subjects with type 2 diabetes.Journal of Korean medical science · 2013Article
- Pharmacokinetic/pharmacodynamic modeling of GLP-1 in healthy rats.Pharmaceutical research · 2012Article
- Racial differences in the association between sex hormone-binding globulin and adiposity in premenopausal women: the BioCycle study.Diabetes care · 2010Article
- Racial and ethnic disparities in assisted reproductive technology outcomes in the United States.Fertility and sterility · 2010Article
- Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysis.Obesity (Silver Spring, Md.) · 2009Article
- Entero-insular axis and postprandial insulin differences in African American and European American children.The American journal of clinical nutrition · 2008Article
- The multiple faces of glucagon-like peptide-1--obesity, appetite, and stress: what is next? A review.Digestive diseases and sciences · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Obese African-American (AA) subjects have higher resting and stimulated insulin concentrations than obese Caucasians (C), which could not be explained by the severity of obesity or the degree of insulin sensitivity. We investigated whether differences in glucagon-like peptide-1 (GLP-1), the most potent incretin that regulates insulin secretion, might explain racial differences in insulin response. Accordingly, we measured fasting and stimulated glucose, insulin, and GLP-1 levels during a 3-h oral glucose tolerance test (OGTT) in 26 obese C (age 38+/-2 y, body mass index 44+/-1 kg/m(2)) and 16 obese AA (age 36+/-2 y, BMI 46+/-2 kg/m(2)) subjects. Corrected insulin response (CIR(30)), a measure of beta-cell activity, whole body insulin sensitivity index (WBISI), and area under the curve (AUC) for insulin, GLP-1, and C-peptide/insulin ratio were computed from the OGTT. Glucose levels, fasting and during the OGTT, were similar between racial groups; 32% of the C and 31% of the AA subjects had impaired glucose tolerance. With a similar WBISI, AAs had significantly higher CIR(30) (2.3+/-0.4 vs 1.01+/-0.1), insulin response (IAUC: 23 974+/-4828 vs 14 478+/-1463), and lower insulin clearance (0.07+/-0.01 vs 0.11+/-0.01) than C (all, P<0.01). Obese AAs also had higher fasting GLP-1 (6.7+/-2.5 vs 4.5+/-1.1) and GLP-1AUC (1174.7+/-412 vs 822.4+/-191) than C (both, P<0.02). Our results indicate that obese AAs had higher concentrations of GLP-1 both at fasting and during the OGTT than obese C. The increased GLP-1 concentration could explain the greater insulin concentration and the increased prevalence of hyperinsulinemia-associated disorders including obesity and type 2 diabetes in AAs.
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