ReviewJournal of thrombosis and thrombolysis2003
The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development.
Review in Journal of thrombosis and thrombolysis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04313790 (Assessment of the Anti-inflammatory Effect of Unfractionated Heparin Administered Either by Intravenous Infusion Versus Subcutaneous Injection in Critically Ill Septic Patients. A Randomized Controlled Trial), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Anti-inflammatory Effect of Unfractionated Heparin Administered Either by Intravenous Infusion Versus Subcutaneous Injection in Critically Ill Septic Patients. A Randomized Controlled Trial
Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation.Journal of extracellular vesicles · 2026Article
- Glycosaminoglycans' Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- The beneficial role of Hepcidin peptide inhibitor in improved the symptoms of COVID-19 in diabetics: anti-inflammatory and potential therapeutic effects.Journal of diabetes and metabolic disorders · 2022Review
- The Potential Role of Heparin in Patients With COVID-19: Beyond the Anticoagulant Effect. A Review.Frontiers in pharmacology · 2020Review
- MMXTherapeutic advances in gastroenterology · 2017Review
- Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage.Current treatment options in neurology · 2016Review
- Comparison of the Effects of Enoxaparin and Heparin on Inflammatory Biomarkers in Patients with ST-segment Elevated Myocardial Infarction: A prospective Open Label Pilot Clinical Trial.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment.Journal of neurosurgery · 2013Article
- Heparin reduces neuroinflammation and transsynaptic neuronal apoptosis in a model of subarachnoid hemorrhage.Translational stroke research · 2012Article
- Nadroparin sodium activates Nrf2/HO-1 pathway in acetic acid-induced colitis in rats.Inflammation · 2012Article
- Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis.Drugs & aging · 2012Article
- Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.World journal of gastroenterology · 2011Review
- Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage.Neurocritical care · 2010Review
- Long-term anticoagulation in Kawasaki disease: Initial use of low molecular weight heparin is a viable option for patients with severe coronary artery abnormalities.Pediatric cardiology · 2010Article
- Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats.The Journal of biological chemistry · 2009Article
- Efficacy of intracolonic administration of low-molecular-weight heparin CB-01-05, compared to other low-molecular-weight heparins and unfractionated heparin, in experimentally induced colitis in rat.Digestive diseases and sciences · 2008Article
- Heparin Attenuates the Expression of TNFalpha-induced Cerebral Endothelial Cell Adhesion Molecule.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Review
- Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin.Respiratory research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerotic disease is recognized as a chronic inflammatory disorder with intermittent and widely variable phases of cellular proliferation and heightened thrombotic activity. The multi-tiered links between inflammation, atherogenesis and thrombogenesis provide a unique opportunity for research and development of pharmaceuticals which target one or more critical pathobiologic steps (Fig. 1). The purpose of the following review on heparin compounds is to comprehensively examine the multi-cellular, pleuripotential effects of a commonly used anticoagulant drug in the context of normal and disease-altered vascular responses and illustrate possible constructs for avenues of subsequent investigation in the field of atherothrombosis. The overview is divided into five integrated parts; antiinflammatory properties of the normal vessel wall, the relationship between glycosaminoglycans and inflammation, heparin-mediated effects on cellular inflammatory responses, association between molecular weight and antiinflammatory capabilities, and oral heparin compounds for achieving prolonged cell-based inhibition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.