ArticleInfection and immunity2003
Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 123 citations in OpenAlex.
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- From Evolutionary Advantage to Disease Agents: Forensic Reevaluation of Host-Microbe Interactions and Pathogenicity.Microbiology spectrum · 2017Review
- A C-Terminal Coiled-Coil Region of CagL is Responsible forEuropean journal of microbiology & immunology · 2016Article
- Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis.Gut microbes · 2016Review
- Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela.The American journal of tropical medicine and hygiene · 2015Article
- Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility.World journal of gastroenterology · 2013Article
- Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome.PloS one · 2012Article
- Intact cag pathogenicity island of Helicobacter pylori without disease association in Kolkata, India.International journal of medical microbiology : IJMM · 2011Article
- Did transmission of Helicobacter pylori from humans cause a disease outbreak in a colony of Stripe-faced Dunnarts (Sminthopsis macroura)?Veterinary research · 2011Article
- Gastric helicobacter spp. Infection in captive neotropical brazilian feline.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.BMC genomics · 2010Article
- The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection is associated with a variety of outcomes ranging from seemingly asymptomatic coexistence to peptic ulcer disease and gastric cancer. The cag pathogenicity island (PAI) contains genes associated with a more aggressive phenotype and has been suggested to be a determinant of severe disease outcome. The cagA gene has served as a marker for the cag PAI. However, the presence of this single gene does not necessarily indicate the presence of a complete set of cag PAI genes. We have analyzed the composition of the cag PAI in 66 clinical isolates obtained from patients with duodenal ulcer, gastric cancer, and nonulcer dyspepsia. Hybridization of DNA to microarrays containing all the genes of the cag PAI showed that 76 and 9% of the strains contained all or none of the cag PAI genes, respectively. Partial deletions of the cag PAI were found in 10 isolates (15%), of which 3 were cagA negative. The ability to induce interleukin-8 (IL-8) production in AGS cells was correlated to the presence of a complete cag PAI. Strains carrying only parts of the island induced IL-8 at levels significantly lower than those induced by cag PAI-positive isolates. The presence of an intact cag PAI correlates with development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease (odds ratio, 5.13; 95% confidence interval, 1.5 to 17.4). Partial deletions of the cag PAI appear to be sufficient to render the organism less pathogenic.
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