ArticleInfection and immunity2003
Differential expression of genes in uninfected and rickettsia-infected Dermacentor variabilis ticks as assessed by differential-display PCR.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Glycine rich proteins of ticks: more than a cement component.Parasitology · 2024Review
- Release the hens: a study on the complexities of guinea fowl as tick control.Journal of medical entomology · 2024Article
- Identification and characterization of a Relish-type NF-κB, DvRelish, inFrontiers in cellular and infection microbiology · 2024Article
- Unpacking the intricacies of Rickettsia-vector interactions.Trends in parasitology · 2021Review
- Article
- First report of Candidatus Rickettsia mendelii in Ixodes brunneus from the United States.Ticks and tick-borne diseases · 2020Article
- Show us your ticks: a survey of ticks infesting dogs and cats across the USA.Parasites & vectors · 2019Article
- Comparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca.Parasites & vectors · 2019Article
- Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission.Parasites & vectors · 2019Review
- Catalase is a determinant of the colonization and transovarial transmission of Rickettsia parkeri in the Gulf Coast tick Amblyomma maculatum.Insect molecular biology · 2017Article
- The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission.Frontiers in cellular and infection microbiology · 2017Review
- Microbial Invasion vs. Tick Immune Regulation.Frontiers in cellular and infection microbiology · 2017Review
- Comparative population genetics of two invading ticks: Evidence of the ecological mechanisms underlying tick range expansions.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis.Insect molecular biology · 2014Article
- Single-tube real-time PCR assay for differentiation of Ixodes affinis and Ixodes scapularis.Ticks and tick-borne diseases · 2014Article
- Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.PloS one · 2014Article
- Hard tick factors implicated in pathogen transmission.PLoS neglected tropical diseases · 2014Review
- Gene expression of tissue-specific molecules in ex vivo Dermacentor variabilis (Acari: Ixodidae) during rickettsial exposure.Journal of medical entomology · 2013Article
- Molecular characterization and tissue-specific gene expression of Dermacentor variabilis α-catenin in response to rickettsial infection.Insect molecular biology · 2012Article
- Impact of climate trends on tick-borne pathogen transmission.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Ticks serve as both the vector and the reservoir for members of the spotted fever group rickettsiae. The molecular interaction(s) that results from this close relationship is largely unknown. To identify genetic factors associated with the tick response to rickettsial infection, we utilized differential-display PCR. The majority of upregulation appeared in the infected tissue. We cloned and sequenced 54 differentially expressed transcripts and compared the sequences to those in the GenBank database. Nine of the 54 clones were assigned putative identities and included a clathrin-coated vesicle ATPase, peroxisomal farnesylated protein, Ena/vasodilator-stimulated phosphoprotein-like protein, alpha-catenin, tubulin alpha-chain, copper-transporting ATPase, salivary gland protein SGS-3 precursor, glycine-rich protein, and Dreg-2 protein. Confirmation of the rickettsial influence on the differential expression in the ovaries for a number of these clones was demonstrated by semiquantitative reverse transcription-PCR and Northern blot analyses, resulting in confirmation of six out of nine and three out of four assessed clones, respectively. Further characterization of the clones identified tissue-dependent expression in the midguts and salivary glands. The potential roles of these molecules in the maintenance and transmission of rickettsiae are discussed.
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