ArticleInfection and immunity2003
Salmonella enterica serovar Typhimurium expressing mutant lipid A with decreased endotoxicity causes maturation of murine dendritic cells.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Structure and function of Salmonella inner membrane.Archives of microbiology · 2026Review
- Protective Immunity Elicited by Oral Immunization of Mice withFrontiers in cellular and infection microbiology · 2016Article
- An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.Microbial cell factories · 2014Article
- Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.Infection and immunity · 2013Article
- Recognition of lipid A variants by the TLR4-MD-2 receptor complex.Frontiers in cellular and infection microbiology · 2013Review
- Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection.PloS one · 2012Article
- Virulence, inflammatory potential, and adaptive immunity induced by Shigella flexneri msbB mutants.Infection and immunity · 2010Article
- Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles.Biochimica et biophysica acta · 2009Article
- Article
- Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major Salmonella component involved in cellular activation is the lipopolysaccharide (LPS) molecule which can act as a dendritic cell (DC) stimulator. The structure of the lipid A domain of the LPS molecule dictates its immunostimulatory capacity with various cell types. In this study, the role of lipid A as an integral component of Salmonella in stimulating murine DCs was studied by using a Salmonella enterica serovar Typhimurium lpxM mutant with defective lipid A. This study revealed that a mutation in lpxM did not significantly affect the ability of bacteria to activate DCs. Although the lpxM mutant less tumor necrosis factor alpha, interleukin-1beta, and inducible nitric oxide synthase than the parental strain, this was only seen at lower multiplicities of infection (MOIs). Both strains upregulated surface molecule expression on DCs and augmented the T-cell-stimulating capacity of these cells in an MOI-independent manner. Thus, the lpxM mutation did not appear to affect the stimulatory capacity of the Salmonella mutant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.