ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.Journal of neurophysiology · 2024Article
- Somatodendritic Release of Cholecystokinin Potentiates GABAergic Synapses Onto Ventral Tegmental Area Dopamine Cells.Biological psychiatry · 2023Article
- Neuropeptide Y1 receptor antagonist but not neuropeptide Y itself increased bone mineral density when locally injected with hyaluronic acid in male Wistar ratsTurkish journal of medical sciences · 2020Article
- Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.Neuropharmacology · 2018Article
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Article
- Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuronal circuits that regulate feeding behavior and metabolism.Trends in neurosciences · 2013Review
- Article
- Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex.Neurobiology of disease · 2012Article
- Activation of NPY type 5 receptors induces a long-lasting increase in spontaneous GABA release from cerebellar inhibitory interneurons.Journal of neurophysiology · 2012Article
- Frequency-dependent release of substance P mediates heterosynaptic potentiation of glutamatergic synaptic responses in the rat visual thalamus.Journal of neurophysiology · 2010Article
- Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors.Endocrinology · 2010Article
- Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system.Journal of neurophysiology · 2009Article
- A neural circuit mechanism integrating motivational state with memory expression in Drosophila.Cell · 2009Article
- Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.Epilepsy research · 2009Article
- Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.Experimental neurology · 2009Article
- Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y.Endocrinology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neuropeptides are commonly colocalized with classical neurotransmitters, yet there is little evidence for peptidergic neurotransmission in the mammalian CNS. We performed whole-cell patch-clamp recording from rodent thalamic brain slices and repetitively stimulated corticothalamic fibers to strongly activate NPY-containing GABAergic reticular thalamic (RT) neurons. This resulted in long-lasting (approximately 10 sec) feedforward slow IPSPs (sIPSPs) in RT cells, which were mimicked and blocked by NPY1 (Y1) receptor agonists and antagonists, respectively, and were present in wild-type mice but absent in NPY-/- mice. NPYergic sIPSPs were mediated via G-proteins and G-protein-activated, inwardly rectifying potassium channels, as evidenced by sensitivity to GDP-beta-S and 0.1 mm Ba2+. In rat RT neurons, NPYergic sIPSPs were also present but were surprisingly absent in the major synaptic targets of RT, thalamic relay neurons, where instead robust GABA(B) IPSPs occurred. In vitro oscillatory network responses in rat thalamus were suppressed and augmented by Y1 agonists and antagonists, respectively. These findings provide evidence for segregation of postsynaptic actions between two targets of RT cells and support a role for endogenously released NPY within RT in the regulation of oscillatory thalamic responses relevant to sleep and epilepsy.
Indexed as
Identifiers
14573544PMC6740476W2115356271What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.