ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Prolonged habituation of the gill-withdrawal reflex in Aplysia depends on protein synthesis, protein phosphatase activity, and postsynaptic glutamate receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
- Habituation and sensitization learning in adult solitary ascidians.Scientific reports · 2026Article
- Brain-wide visual habituation networks in wild type and fmr1 zebrafish.Nature communications · 2022Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Possible novel features of synaptic regulation during long-term facilitation inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Subcellular Dissection of a Simple Neural Circuit: Functional Domains of the Mauthner-Cell During Habituation.Frontiers in neural circuits · 2021Article
- Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria.Cell reports · 2019Article
- Are the persistent effects of "gate control" stimulation on nociception a form of generalization of habituation that is endocannabinoid-dependent?Neurobiology of learning and memory · 2018Article
- Habituation based synaptic plasticity and organismic learning in a quantum perovskite.Nature communications · 2017Article
- Phylogenetic origins of biological cognition: convergent patterns in the early evolution of learning.Interface focus · 2017Review
- Article
- Long-term habituation of the C-start escape response in zebrafish larvae.Neurobiology of learning and memory · 2016Article
- Transcriptional analysis of a whole-body form of long-term habituation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Network processes involved in the mediation of short-term habituation in Aplysia: contribution of intrinsic regulation of excitability and synaptic augmentation.Frontiers in integrative neuroscience · 2014Article
- Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Learning and memory in zebrafish larvae.Frontiers in neural circuits · 2013Review
- Central gene expression changes associated with enhanced neuroendocrine and autonomic response habituation to repeated noise stress after voluntary wheel running in rats.Frontiers in physiology · 2013Article
- Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.Brain and behavior · 2012Article
- Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Habituation of the C-start response in larval zebrafish exhibits several distinct phases and sensitivity to NMDA receptor blockade.PloS one · 2011Article
- Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.Journal of neurophysiology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite representing perhaps the simplest form of memory, habituation is not yet well understood mechanistically. We used a reduced preparation to analyze the neurobiological mechanisms of persistent habituation of a simple behavior, the defensive withdrawal reflex of the marine snail Aplysia californica. This preparation permits direct infusion of drugs into the abdominal ganglion during training via a cannula in the abdominal artery. Using siphon-elicited gill withdrawal, we demonstrate habituation of withdrawal that persists for 1-6 hr after repeated, spaced blocks of habituating stimulation. This form of habituation exhibits site specificity and requires protein synthesis because it is blocked by the presence of anisomycin, a protein synthesis inhibitor. We also find that habituation of gill withdrawal requires protein phosphatase activity, because it is blocked by okadaic acid, an inhibitor of protein phosphatase. Finally, habituation of gill withdrawal requires activation of NMDA-type and AMPA-type postsynaptic receptors within the abdominal ganglion, because it is blocked by infusion of dl-2-amino-5-phosphonovaleric acid or 6,7-dinitroquinoxaline-2,3-dione. The requirement for activation of postsynaptic glutamatergic receptors indicates that homosynaptic depression, an exclusively presynaptic mechanism that has been implicated previously in habituation in Aplysia, does not play a significant role in persistent habituation of the withdrawal reflex. Our results indicate that postsynaptic mechanisms, possibly including modulation of glutamate receptor function, play a major, heretofore unsuspected, role in habituation in Aplysia.
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14573538PMC6740459W1605215937What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.