ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Sodium Butyrate-Assisted Induction of Posterior Pre-Neural Progenitors from Pluripotent Stem Cells.International journal of molecular sciences · 2026Article
- GCN2-Mediated eIF2α Phosphorylation Is Required for Central Nervous System Remyelination.International journal of molecular sciences · 2025Article
- Regulators of Oligodendrocyte Differentiation.Cold Spring Harbor perspectives in biology · 2024Review
- White matter integrity in mice requires continuous myelin synthesis at the inner tongue.Nature communications · 2022Article
- Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke.Theranostics · 2022Article
- Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting.Cell death and differentiation · 2020Article
- Stage-specific regulation of oligodendrocyte development by Hedgehog signaling in the spinal cord.Glia · 2020Article
- Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome.Journal of neurodevelopmental disorders · 2019Article
- Peptide-modified, hyaluronic acid-based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering.Journal of biomedical materials research. Part A · 2019Article
- Molecular Control of Oligodendrocyte Development.Trends in neurosciences · 2019Review
- Article
- FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord.Neural development · 2018Article
- Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.Nature communications · 2018Article
- Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage.Glia · 2015Review
- Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.Developmental cell · 2015Article
- Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region.Neurobiology of disease · 2015Article
- Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination.Brain : a journal of neurology · 2015Article
- A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis.Journal of central nervous system disease · 2015Article
- An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.Neuron · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In developing neural tube, the basic helix-loop-helix (bHLH) transcription factor Olig2 interacts with the homeodomain transcription factor Nkx2.2 at two distinct stages. During neuronogenesis, a cross-repressive interaction appears to establish the precise boundary between the p3 and pMN domains. At later times, a cooperative interaction is noted because Nkx2.2 promotes maturation of oligodendrocyte progenitor cells specified by expression of Olig2. We show here that the Olig2 protein can form a physical complex with Nkx2.2 protein in mammalian cells and yeast two-hybrid trap assay. This interaction is specific because Olig2 does not bind to a biologically irrelevant homeodomain transcription factor (Nkx6.1), and Nkx2.2 does not interact with a biologically irrelevant bHLH protein (NeuroD). Deletion mapping analysis suggests that formation of an Olig2-Nkx2.2 physical complex is insufficient for the induction of oligodendrocyte progenitors in developing spine; however, the protein-protein interaction observed might be important for the cross-repressive interaction between Olig2 and Nkx2.2 that helps to establish the pMN-p3 boundary in the developing spinal cord.
Indexed as
Identifiers
14573534PMC6740479W2135241886What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.