ArticleGenetics2003
Large-scale adaptive hitchhiking upon high recombination in Drosophila simulans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How species evolve collectively: implications of gene flow and selection for the spread of advantageous alleles.Molecular ecology · 2004Pooled it
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data.Genetics · 2015Article
- Allele frequency changes due to hitch-hiking in genomic selection programs.Genetics, selection, evolution : GSE · 2014Article
- Reduced polymorphism associated with X chromosome meiotic drive in the stalk-eyed fly Teleopsis dalmanni.PloS one · 2011Article
- Contrasting evolution of diversity at two disease-associated chicken genes.Immunogenetics · 2009Article
- Genetic hitchhiking in a subdivided population of Mytilus edulis.BMC evolutionary biology · 2008Article
- Gene expression profiling of a Zn-tolerant and a Zn-sensitive Suillus luteus isolate exposed to increased external zinc concentrations.Mycorrhiza · 2007Article
- Unusual pattern of nucleotide sequence variation at the OS-E and OS-F genomic regions of Drosophila simulans.Genetics · 2007Article
- Unexpected high polymorphism at the FABP4 gene unveils a complex history for pig populations.Genetics · 2006Article
- Genome-wide DNA polymorphism analyses using VariScan.BMC bioinformatics · 2006Article
- Contrasted polymorphism patterns in a large sample of populations from the evolutionary genetics model Drosophila simulans.Genetics · 2006Article
- Article
- DNA sequence polymorphism and divergence at the erect wing and suppressor of sable loci of Drosophila melanogaster and D. simulans.Genetics · 2005Article
- Article
- Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.Genetics · 2005Article
- Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.Genetics · 2005Article
- Article
- Linkage disequilibrium as a signature of selective sweeps.Genetics · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection is expected to leave a characteristic footprint on neighboring nucleotide variation through the effects of genetic linkage. The size of the region affected is proportional to the strength of selection and greatly reduced with the recombinational distance from the selected site. Thus, the genomic footprint of selection is generally believed to be restricted to a small DNA stretch in normal and highly recombining regions. Here, we study the effect of selection on linked polymorphism (hitchhiking effect) by surveying nucleotide variation across a highly recombining approximately 88-kb genomic fragment in an African population of Drosophila simulans. We find a core region of up to 38 kb with a major haplotype at intermediate frequency. The extended haplotype structure that gradually vanishes until disappearing is unusual for a highly recombining region. Both the presence in the structured genomic domain of a single major haplotype depleted of variability and the detected spatial pattern of variation along the approximately 88-kb fragment are incompatible with neutral predictions in a panmictic population. A major role of demographic effects could also be discarded. The observed pattern of variation clearly provides evidence that directional selection has acted recently on this region, sweeping out variation around a strongly adaptive mutation. Our findings suggest a major role of positive selection in shaping DNA variability even in highly recombining regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.