ArticleGenetics2003
A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Meiotic cohesion requires Sirt1 and preserving its activity in aging oocytes reduces missegregation.EMBO reports · 2025Article
- Basal autophagy during meiotic prophase I is required for accurate chromosome segregation inMolecular biology of the cell · 2025Article
- An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes.G3 (Bethesda, Md.) · 2024Article
- Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase.Current biology : CB · 2024Article
- B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster.Current biology : CB · 2023Article
- Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila.Disease models & mechanisms · 2023Article
- Targeting Polo-like kinase in space and time during C. elegans meiosis.Cell cycle (Georgetown, Tex.) · 2021Review
- Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytes.Chromosoma · 2019Article
- Functional Consequences of the Evolution of Matrimony, a Meiosis-Specific Inhibitor of Polo Kinase.Molecular biology and evolution · 2019Article
- Article
- B Chromosomes in theGenes · 2018Review
- Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.PLoS biology · 2013Article
- Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Nondisjunctional segregations in Drosophila female meiosis I are preceded by homolog malorientation at metaphase arrest.Genetics · 2013Article
- The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome.Genome biology · 2012Article
- polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster.G3 (Bethesda, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila oocytes, euchromatic homolog-homolog associations are released at the end of pachytene, while heterochromatic pairings persist until metaphase I. A screen of 123 autosomal deficiencies for dominant effects on achiasmate chromosome segregation has identified a single gene that is haplo-insufficient for homologous achiasmate segregation and whose product may be required for the maintenance of such heterochromatic pairings. Of the deficiencies tested, only one exhibited a strong dominant effect on achiasmate segregation, inducing both X and fourth chromosome nondisjunction in FM7/X females. Five overlapping deficiencies showed a similar dominant effect on achiasmate chromosome disjunction and mapped the haplo-insufficient meiotic gene to a small interval within 66C7-12. A P-element insertion mutation in this interval exhibits a similar dominant effect on achiasmate segregation, inducing both high levels of X and fourth chromosome nondisjunction in FM7/X females and high levels of fourth chromosome nondisjunction in X/X females. The insertion site for this P element lies immediately upstream of CG18543, and germline expression of a UAS-CG18543 cDNA construct driven by nanos-GAL4 fully rescues the dominant meiotic defect. We conclude that CG18543 is the haplo-insufficient gene and have renamed this gene matrimony (mtrm). Cytological studies of prometaphase and metaphase I in mtrm hemizygotes demonstrate that achiasmate chromosomes are not properly positioned with respect to their homolog on the meiotic spindle. One possible, albeit speculative, interpretation of these data is that the presence of only a single copy of mtrm disrupts the function of whatever "glue" holds heterochromatically paired homologs together from the end of pachytene until metaphase I.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.