ArticleGenetics2003
Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 117 citations in OpenAlex.
- Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024Article
- Temperature change exerts sex-specific effects on behavioural variation.Proceedings. Biological sciences · 2023Article
- Patterns of Population Structure and Introgression Among Recently Differentiated Drosophila melanogaster Populations.Molecular biology and evolution · 2022Article
- Strong evidence for the adaptive walk model of gene evolution in Drosophila and Arabidopsis.PLoS biology · 2022Article
- Experimental sexual selection affects the evolution of physiological and life-history traits.Journal of evolutionary biology · 2022Article
- Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila.PLoS genetics · 2021Article
- Flight Burst Duration as an Indicator of Flight Ability and Physical Fitness in Two Species of Tephritid Fruit Flies.Journal of insect science (Online) · 2020Article
- Interactions with ectoparasitic mites induce host metabolic and immune responses in flies at the expense of reproduction-associated factors.Parasitology · 2020Article
- Transcriptome analysis ofEcology and evolution · 2020Article
- Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis inGenetics · 2019Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Effects of starvation on the carbohydrate metabolism inBiology open · 2017Article
- Metabolic rate and hypoxia tolerance are affected by group interactions and sex in the fruit fly (Biology open · 2017Article
- Knockdown of five trehalase genes using RNA interference regulates the gene expression of the chitin biosynthesis pathway in Tribolium castaneum.BMC biotechnology · 2016Article
- Measurement of Carbon Dioxide Production from Radiolabeled Substrates in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2016Article
- Natural variability in Drosophila larval and pupal NaCl tolerance.Journal of insect physiology · 2016Article
- Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior.Genes, brain, and behavior · 2016Article
- The influence of mitonuclear genetic variation on personality in seed beetles.Proceedings. Biological sciences · 2014Article
- Predicting performance and plasticity in the development of respiratory structures and metabolic systems.Integrative and comparative biology · 2014Article
- Dominant PRPF31 mutations are hypostatic to a recessive CNOT3 polymorphism in retinitis pigmentosa: a novel phenomenon of "linked trans-acting epistasis".Annals of human genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We employed quantitative trait locus (QTL) mapping to dissect the genetic architecture of a hierarchy of functionally related physiological traits, including metabolic enzyme activity, metabolite storage, metabolic rate, and free-flight performance in recombinant inbred lines of Drosophila melanogaster. We identified QTL underlying variation in glycogen synthase, hexokinase, phosphoglucomutase, and trehalase activity. In each case variation mapped away from the enzyme-encoding loci, indicating that trans-acting regions of the genome are important sources of variation within the metabolic network. Individual QTL associated with variation in metabolic rate and flight performance explained between 9 and 35% of the phenotypic variance. Bayesian QTL analysis identified epistatic effects underlying variation in flight velocity, metabolic rate, glycogen content, and several metabolic enzyme activities. A region on the third chromosome was associated with expression of the glucose-6-phosphate branchpoint enzymes and with metabolic rate and flight performance. These genomic regions are of special interest as they may coordinately regulate components of energy metabolism with effects on whole-organism physiological performance. The complex biochemical network is encoded by an equally complex network of interacting genetic elements with potentially pleiotropic effects. This has important consequences for the evolution of performance traits that depend upon these metabolic networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.