ArticleGenetics2003
Dominance and overdominance of mildly deleterious induced mutations for fitness traits in Caenorhabditis elegans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.Genetics · 2026Article
- Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations.bioRxiv : the preprint server for biology · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Constraining models of dominance for nonsynonymous mutations in the human genome.PLoS genetics · 2024Article
- Revisiting Dominance in Population Genetics.Genome biology and evolution · 2024Review
- Background Selection Does Not Mimic the Patterns of Genetic Diversity Produced by Selective Sweeps.Genetics · 2020Article
- Effect of partial selfing and polygenic selection on establishment in a new habitat.Evolution; international journal of organic evolution · 2019Article
- Fitness and Genomic Consequences of Chronic Exposure to Low Levels of Copper and Nickel inG3 (Bethesda, Md.) · 2019Article
- Heterogeneous gene duplications can be adaptive because they permanently associate overdominant alleles.Evolution letters · 2017Article
- Experimental Evolution withGenetics · 2017Review
- Obstruction of adaptation in diploids by recessive, strongly deleterious alleles.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dominance genetic variance for traits under directional selection in Drosophila serrata.Genetics · 2015Article
- Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.PLoS genetics · 2013Article
- Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans.Genetics · 2011Article
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- Life cycle and population growth rate of Caenorhabditis elegans studied by a new method.BMC ecology · 2009Article
- Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa).BMC evolutionary biology · 2008Article
- Selection against males in Caenorhabditis elegans under two mutational treatments.Proceedings. Biological sciences · 2007Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We estimated the average dominance coefficient of mildly deleterious mutations (h, the proportion by which mutations in the heterozygous state reduce fitness components relative to those in the homozygous state) in the nematode Caenorhabditis elegans. From 56 worm lines that carry mutations induced by the point mutagen ethyl methanesulfonate (EMS), we selected 19 lines that are relatively high in fitness and estimated the viabilities, productivities, and relative fitnesses of heterozygotes and homozygotes compared to the ancestral wild type. There was very little effect of homozygous or heterozygous mutations on egg-to-adult viability. For productivity and relative fitness, we found that the average dominance coefficient, h, was approximately 0.1, suggesting that mildly deleterious mutations are on average partially recessive. These estimates were not significantly different from zero (complete recessivity) but were significantly different from 0.5 (additivity). In addition, there was a significant amount of variation in h among lines, and analysis of average dominance coefficients of individual lines suggested that several lines showed overdominance for fitness. Further investigation of two of these lines partially confirmed this finding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.