ArticleGenetics2003
The G1 cyclin Cln3p controls vacuolar biogenesis in Saccharomyces cerevisiae.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Multiple metabolic requirements for size homeostasis and initiation of division inMicrobial cell (Graz, Austria) · 2014Article
- Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.Genes & development · 2011Article
- Control of transcription by cell size.PLoS biology · 2010Article
- The coiled-coil protein VIG1 is essential for tethering vacuoles to mitochondria during vacuole inheritance of Cyanidioschyzon merolae.The Plant cell · 2010Article
- Measurement of mass, density, and volume during the cell cycle of yeast.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Daughter-specific transcription factors regulate cell size control in budding yeast.PLoS biology · 2009Article
- Vacuole inheritance regulates cell size and branching frequency of Candida albicans hyphae.Molecular microbiology · 2009Article
- The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance.Developmental cell · 2008Article
- The size of the nucleus increases as yeast cells grow.Molecular biology of the cell · 2007Article
- Ribosome biogenesis is sensed at the Start cell cycle checkpoint.Molecular biology of the cell · 2007Article
- Bem1p, a scaffold signaling protein, mediates cyclin-dependent control of vacuolar homeostasis in Saccharomyces cerevisiae.Genes & development · 2005Article
- ABG1, a novel and essential Candida albicans gene encoding a vacuolar protein involved in cytokinesis and hyphal branching.Eukaryotic cell · 2005Article
- A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae.Current genetics · 2004Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
How organelle biogenesis and inheritance is linked to cell division is poorly understood. In the budding yeast Saccharomyces cerevisiae the G(1) cyclins Cln1,2,3p control initiation of cell division. Here we show that Cln3p controls vacuolar (lysosomal) biogenesis and segregation. First, loss of Cln3p, but not Cln1p or Cln2p, resulted in vacuolar fragmentation. Although the vacuoles of cln3delta cells were fragmented, together they occupied a large space, which accounted for a significant fraction of the overall cell size increase in cln3delta cells. Second, cytosol prepared from cells lacking Cln3p had reduced vacuolar homotypic fusion activity in cell-free assays. Third, vacuolar segregation was perturbed in cln3delta cells. Our findings reveal a novel role for a eukaryotic G(1) cyclin in cytoplasmic organelle biogenesis and segregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.