ArticleNeurobiology of disease2003
DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles.
Article in Neurobiology of disease, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Translational psychiatry · 2026Pooled it
- Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer's disease.Translational psychiatry · 2024Pooled it
- Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease.BMC research notes · 2018Article
- Post-mortem molecular profiling of three psychiatric disorders.Genome medicine · 2017Article
- The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.Journal of psychiatric research · 2016Article
- Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.PloS one · 2014Article
- Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia.BMC genomics · 2013Article
- Circadian patterns of gene expression in the human brain and disruption in major depressive disorder.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability.Current genomics · 2010Article
- Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches.Biomarkers in medicine · 2009Article
- Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection.Journal of neuroscience methods · 2009Article
- Target identification for CNS diseases by transcriptional profiling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Review
- Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum.PloS one · 2008Article
- Stress-induced changes in primate prefrontal profiles of gene expression.Molecular psychiatry · 2007Review
- Microarrays and the microscope: balancing throughput with resolution.The Journal of physiology · 2006Review
- Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Aging and gene expression in the primate brain.PLoS biology · 2005Article
- Systematic analysis of gene expression in human brains before and after death.Genome biology · 2005Article
- Dysregulation of the fibroblast growth factor system in major depression.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Transcriptional profiles within discrete human brain regions are likely to reflect structural and functional specialization. Using DNA microarray technology, this study investigates differences in transcriptional profiles of highly divergent brain regions (the cerebellar cortex and the cerebral cortex) as well as differences between two closely related brain structures (the anterior cingulate cortex and the dorsolateral prefrontal cortex). Replication of this study across three independent laboratories, to address false-positive and false-negative results using microarray technology, is also discussed. We find greater than a thousand transcripts to be differentially expressed between cerebellum and cerebral cortex and very few transcripts to be differentially expressed between the two neocortical regions. We further characterized transcripts that were found to be specifically expressed within brain regions being compared and found that ontological classes representing signal transduction machinery, neurogenesis, synaptic transmission, and transcription factors were most highly represented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.