ArticleMedical & biological engineering & computing2003
Simulation framework for electrophysiological networks: effect of syncytial properties on smooth-muscle synaptic potentials.
Article in Medical & biological engineering & computing, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- A computational model of urinary bladder smooth muscle syncytium : validation and investigation of electrical properties.Journal of computational neuroscience · 2015Article
- Effects of carbenoxolone on syncytial electrical properties and junction potentials of guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived and numerically solved, and the results of the simulation agree with previous results obtained analytically. An enhanced model was also proposed, incorporating an additional (junctional) capacitance in the network. The correctness of the model was verified, and the effect of the extra capacitance on the synaptic potentials was explored. It was found that, with a junctional capacitance C(i) of 1.4 x 10(-10) F incorporated, the peak amplitude of the spontaneous excitatory junction potential V(peak) declined by approximately 13% at node 0 and by approximately 37% at node 3x for a system size of 9(3). Similar results were obtained for different system sizes. V(peak) also declined as the junctional capacitance Ci was increased. In a system of size 11(30, a 200-fold increase in C(i) induced a 55% reduction at node 0. It is suggested that the type of modular simulation framework developed here may find general applicability for simulations of other physiological systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.