ArticleJournal of neurology, neurosurgery, and psychiatry2003
Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.
Article in Journal of neurology, neurosurgery, and psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 61 citations in OpenAlex.
- Review
- Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care.Journal of food and drug analysis · 2019Article
- Cyanides in the environment-analysis-problems and challenges.Environmental science and pollution research international · 2017Review
- Determination of cyanide in urine and saliva samples by ion chromatography with pulsed amperometric detection.Monatshefte fur chemie · 2017Article
- Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.International journal of health geographics · 2013Article
- Grappling the high altitude for safe edible bamboo shoots with rich nutritional attributes and escaping cyanogenic toxicity.BioMed research international · 2013Article
- Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general health condition.BMC infectious diseases · 2011Article
- Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.Metabolic brain disease · 2011Review
- Auditory and visual novelty processing in normally-developing Kenyan children.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe occurrence of ataxic polyneuropathy in an endemic area in south west Nigeria has been attributed to exposure to cyanide from cassava foods. However, it has been shown that the prevalence of ataxic polyneuropathy is not high in several communities in the tropics where exposure to cyanide from cassava foods is high.
objectivesTo determine the incidence of ataxic polyneuropathy in an endemic community, and to compare the intake of cassava foods, exposure to cyanide, and levels of thiols in cases and controls.
methodsA cohort of 3167 healthy subjects aged 10 years and over in Ososa, Nigeria, was followed for two years, screened, and examined neurologically. Ataxic polyneuropathy was diagnosed if sensory polyneuropathy and sensory gait ataxia were both present. Controls were selected randomly within 10 year age groups of subjects who screened negative. Intake of cassava foods, exposure to cyanide, concentrations of thiols (glutathione, cysteine, and gamma glutamylcysteine) in plasma, and visual evoked potentials were measured.
resultsPerson-years of follow up were 6246 for 1469 male and 1698 female subjects in the cohort. The incidence of ataxic polyneuropathy was 64 per 10,000 person-years (31 for male and 93 for female subjects). Multivariate odd ratios were 0.78 (95% CI 0.23 to 2.61) for intake of the commonest cassava food, and 1.64 (0.56 to 5.09) for concentration of thiocyanate in plasma. The concentration of thiols was less than the reference limits in two controls, but in none of the cases. The latency of P100 was prolonged in 20 cases (69%) compared with 14 controls (42%) (p<0.05).
conclusionsThe incidence of ataxic polyneuropathy is high in Ososa, Nigeria, but the intake of cassava foods, exposure to cyanide, and levels of thiols, are not related to the occurrence. These findings do not suggest that cyanide is the cause of endemic ataxic polyneuropathy.
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