ReviewJournal of neurology, neurosurgery, and psychiatry2003
Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC.
Review in Journal of neurology, neurosurgery, and psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Volume Analysis of Brain Cognitive Areas in Alzheimer's Disease: Interim 3-Year Results from the ASCOMALVA Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Trial
- Global cognitive impairment should be taken into account in SPECT-neuropsychology correlations: the example of verbal memory in very mild Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2005Trial
- Apathy in Dementia: A Pilot Study Providing Insights from Neuropsychiatric and Radiological Perspectives.Journal of clinical medicine · 2025Article
- Effect of Treatment of the Cholinergic Precursor Choline Alphoscerate in Mild Cognitive Dysfunction: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Article
- The impact of medial temporal and parietal atrophy on cognitive function in dementia.Scientific reports · 2024Article
- Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia.Brain sciences · 2022Article
- Evaluation of MR Visual Rating Scales in Major Forms of Dementia.Journal of neurosciences in rural practice · 2021Article
- Observational
- Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Structural Image Analysis of the Brain in Neuropsychology Using Magnetic Resonance Imaging (MRI) Techniques.Neuropsychology review · 2015Review
- The effect of galantamine on brain atrophy rate in subjects with mild cognitive impairment is modified by apolipoprotein E genotype: post-hoc analysis of data from a randomized controlled trial.Alzheimer's research & therapy · 2014Article
- A survey of FDG- and amyloid-PET imaging in dementia and GRADE analysis.BioMed research international · 2014Review
- Increase of theta frequency is associated with reduction in regional cerebral blood flow only in subjects with mild cognitive impairment with higher upper alpha/low alpha EEG frequency power ratio.Frontiers in behavioral neuroscience · 2013Article
- The clinical use of structural MRI in Alzheimer disease.Nature reviews. Neurology · 2010Review
- Fluorodeoxyglucose-positron emission tomography in the differential diagnosis of early-onset dementia: a prospective, community-based study.BMC neurology · 2009Article
- Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized method.Brain : a journal of neurology · 2008Article
- Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?Journal of Alzheimer's disease : JAD · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Neuroimaging is a mainstay in the differential diagnosis of patients with cognitive impairment. The often equivocal clinical pictures, the prognostic uncertainty of the earliest stages of mild cognitive impairment, and the subtle brain changes mean that neuroimaging techniques are of potentially great incremental diagnostic value. A number of methods, ranging from very simple subjective visual ratings to highly sophisticated computerised tools, have been developed, which allow rating of structural and functional brain changes. The choice of the method is not obvious, and current guidelines provide no indications on which tools should be preferred. In this paper, we give indications for tools with demonstrated accuracy for detecting regional atrophy, cerebrovascular disease, and regional brain function, and discuss these according to increasing technological complexity, ranging from those with high feasibility that can be used at the patient's bedside to highly technological ones that require trained personnel and specific hardware and software.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.