ArticleHuman genetics2003
Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.American journal of human genetics · 2013Article
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- Linkage and association of phospholipid transfer protein activity to LASS4.Journal of lipid research · 2011Article
- Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16.Human genetics · 2011Article
- Genetic causes of high and low serum HDL-cholesterol.Journal of lipid research · 2010Review
- Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- A gene frequency model for QTL mapping using Bayesian inference.Genetics, selection, evolution : GSE · 2010Article
- Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families.Human genetics · 2010Article
- Joint linkage and segregation analysis under multiallelic trait inheritance: simplifying interpretations for complex traits.Genetic epidemiology · 2010Article
- Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.European journal of human genetics : EJHG · 2010Article
- Association of apolipoprotein A1-C3 gene cluster polymorphisms with gallstone disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2007Article
- Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Article
- Article
- Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.Human genetics · 2005Article
- Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension.American journal of human genetics · 2005Article
- Joint oligogenic segregation and linkage analysis using bayesian Markov chain Monte Carlo methods.Molecular biotechnology · 2004Review
- Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2.American journal of human genetics · 2004Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The APOA1-C3-A4-A5 gene complex encodes genes whose products are implicated in the metabolism of HDL and/or triglycerides. Although the relationship between polymorphisms in this gene cluster and dyslipidemias was first reported more than 15 years ago, association and linkage results have remained inconclusive. This is due, in part, to the oligogenic and multivariate nature of dyslipidemic phenotypes. Therefore, we investigate evidence of linkage of APOC3 and HDL using two samples of dyslipidemic pedigrees: familial combined hyperlipidemia (FCHL) and isolated low-HDL (ILHDL). We used a strategy that deals with several difficulties inherent in the study of complex traits: by using a Bayesian Markov Chain Monte Carlo (MCMC) approach we allow for oligogenic trait models, as well as simultaneous incorporation of covariates, in the context of multipoint analysis. By using this approach on extended pedigrees we provide evidence of linkage of APOC3 and HDL level variation in two samples with different ascertainment. In addition to APOC3, we estimate that two to three genes, each with a substantial effect on total variance, are responsible for HDL variation in both data sets. We also provide evidence, using the FCHL data set, for a pleiotropic effect between HDL, HDL3 and triglycerides at the APOC3 locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.