ArticleHuman genetics2003
Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Y-chromosome genes associated with sertoli cell-only syndrome identified by array comparative genome hybridization.Biomedical journal · 2023Article
- Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis.Theranostics · 2020Article
- Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice.Cell death & disease · 2019Article
- Distinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome.Journal of assisted reproduction and genetics · 2016Article
- Expression level of chromodomain Y (CDY): potential marker for prediction of sperm recovery in non-obstructive azoospermia.International journal of reproductive biomedicine · 2016Article
- Copy-number variations in Y-chromosomal azoospermia factor regions identified by multiplex ligation-dependent probe amplification.Journal of human genetics · 2015Article
- Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia.Asian journal of andrology · 2012Article
- Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram.PloS one · 2012Article
- Article
- Azoospermia factor and male infertility.Reproductive medicine and biology · 2010Review
- Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?Journal of biomedicine & biotechnology · 2010Review
- The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.Cancer research · 2009Article
- Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.The Journal of biological chemistry · 2008Article
- The Y deletion gr/gr and susceptibility to testicular germ cell tumor.American journal of human genetics · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CDY family of genes is of special interest because some of them are included in chromosome-Y microdeletions detected among infertile men and are apparently involved in the spermiogenetic process. In this study, we employed the reverse transcriptase/polymerase chain reaction technique to test the RNA expression of the various transcripts of these genes in testicular biopsies of 84 azoospermic men who had been classified by comprehensive histology and cytology analyses. We also evaluated the feasibility of detecting CDY expression in biopsies taken by testicular sperm extraction versus acquisition by aspiration. There was a significant association between the type of testicular impairment and the expression of CDY1 and CDY2 transcripts. CDY2 was expressed whenever germ cells were present, but CDY1 major and especially CDY1 minor and short transcripts were identified almost exclusively when mature spermatids/spermatozoa were detected. The expression of CDY1 minor and short transcripts detected in aspirated specimens was less efficient than that in testicular tissue acquired by extraction. It is suggested that CDY2 is apparently required in the early stages of spermatogenesis, whereas CDY1 transcripts are required later on in the process. The findings of this study imply different functional roles for CDY isoforms during spermatogenesis. However, in consideration of the high levels of identity between CDY1 and CDY2 (98% at the protein level), the delayed up-regulation of CDY1 transcripts could be attributable to temporal changes in dosage requirements.
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