ArticleThe Journal of experimental medicine2003
Elimination in vivo of developing T cells by natural killer cells.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Thymic NK-Cells and Their Potential in Cancer Immunotherapy.ImmunoTargets and therapy · 2024Review
- Review
- Natural Killer Cell Regulation of B Cell Responses in the Context of Viral Infection.Viral immunology · 2020Review
- [Research on the negative immune regulation of NK cells in patients with primary immune thrombocytopenia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity.eLife · 2017Article
- Facial Nerve Recovery in KbDb and C1q Knockout Mice: A Role for Histocompatibility Complex 1.Plastic and reconstructive surgery. Global open · 2016Article
- MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NK cells and their ability to modulate T cells during virus infections.Critical reviews in immunology · 2014Review
- A lack of immune system genes causes loss in high frequency hearing but does not disrupt cochlear synapse maturation in mice.PloS one · 2014Article
- NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses.Frontiers in immunology · 2012Article
- Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity.Neuron · 2009Article
- Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels.The Journal of experimental medicine · 2009Article
- H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.Immunity · 2007Article
- Natural killer cells and autoimmunity.Arthritis research & therapy · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer cells gauge the absence of self class I MHC on susceptible target cells by means of inhibitory receptors such as members of the Ly49 family. To initiate killing by natural killer cells, a lack of inhibitory signals must be accompanied by the presence of activating ligands on the target cell. Although natural killer cell-mediated rejection of class I MHC-deficient bone marrow (BM) grafts is a matter of record, little is known about the targeting in vivo of specific cellular subsets by natural killer cells. We show here that development of class I MHC-negative thymocytes is delayed as a result of natural killer cell toxicity after grafting of a class I MHC-positive host with class I MHC-negative BM. Double positive thymocytes that persist in the presence of natural killer cells display an unusual T cell receptor-deficient phenotype, yet nevertheless give rise to single positive thymocytes and yield mature class I MHC-deficient lymphocytes that accumulate in the class I MHC-positive host. The resulting class I MHC-deficient CD8 T cells are functional and upon activation remain susceptible to natural killer cell toxicity in vivo. Reconstitution of class I MHC-deficient BM precursors with H2-K(b) by retroviral transduction fully restores normal thymic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.