ArticleImmunogenetics2003
Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populations.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Mergers and migrations: drivers of population genetic structure in a captive rhesus macaque colony.BMC genomics · 2026Article
- The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises.Biology · 2025Article
- Reference Intervals for Total T4 and Free T4 in Cynomolgus Macaques (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Quantification of Viral RNA and DNA Positive Cells in Tissues From Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus Infected Controller and Progressor Rhesus Macaques.Frontiers in microbiology · 2019Article
- Comparative genomics of the human, macaque and mouse major histocompatibility complex.Immunology · 2017Review
- SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- SIV Infection FacilitatesFrontiers in microbiology · 2016Article
- Comprehensive identification of MHC class II alleles in a cohort of Chinese rhesus macaques.Immunogenetics · 2014Article
- Differential recombination dynamics within the MHC of macaque species.Immunogenetics · 2014Article
- Genetic diversity and differentiation of the rhesus macaque (Macaca mulatta) population in western Sichuan, China, based on the second exon of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles.BMC evolutionary biology · 2014Article
- Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques.Immunogenetics · 2013Article
- SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans.Retrovirology · 2013Review
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Genetic diversity and population structure in wild Sichuan rhesus macaques.Molecular biology reports · 2013Article
- Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease.Clinical immunology (Orlando, Fla.) · 2013Article
- Ecological genetics of Chinese rhesus macaque in response to mountain building: all things are not equal.PloS one · 2013Article
- Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).BMC evolutionary biology · 2012Article
- Reproductive efficiency of captive Chinese- and Indian-origin rhesus macaque (Macaca mulatta) females.American journal of primatology · 2012Article
- Article
- Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region.Immunogenetics · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A thoroughly characterized breeding colony of 172 pedigreed rhesus macaques was used to analyze exon 2 of the polymorphic Mamu- DPB1, -DQA1, -DQB1, and - DRB loci. Most of the monkeys or their ancestors originated in India, though the panel also included animals from Burma and China, as well as some of unknown origin and mixed breeds. In these animals, mtDNA appears to correlate with the aforementioned geographic origin, and a large number of Mamu class II alleles were observed. The different Mamu- DPB1 alleles were largely shared between monkeys of different origin, whereas in humans particular alleles appear to be unique for ethnic populations. In contrast to Mamu-DPB1, the highly polymorphic - DQA1/DQB1 alleles form tightly linked pairs that appear to be about two-thirds population specific. For most of the DQA1/DQB1 pairs, Mamu- DRB region configurations present on the same chromosome have been ascertained, resulting in 41 different -DQ/DRB haplotypes. These distinct DQ/DRB haplotypes seem to be specific for monkeys of a determined origin. Thus, in evolutionary terms, the Mamu-DP, -DQ, and -DR regions show increasing instability with regard to allelic polymorphism, such as for -DP/DQ, or gene content and allelic polymorphism, such as for -DR, resulting in population-specific class II haplotypes. Furthermore, novel haplotypes are generated by recombination-like events. The results imply that mtDNA analysis in combination with Mhc typing is a helpful tool for selecting animals for biomedical experiments.
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