ArticleEMBO reports2003
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
Article in EMBO reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Review
- Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation.Oncogene · 2018Article
- Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.Frontiers of medicine · 2018Review
- Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.EMBO molecular medicine · 2018Article
- Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.Oncogene · 2016Article
- Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.Neoplasia (New York, N.Y.) · 2014Article
- Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia.Leukemia · 2014Article
- Article
- Role of STRAP in regulating GSK3β function and Notch3 stabilization.Cell cycle (Georgetown, Tex.) · 2011Article
- Notch Signaling in T-Cell Development and T-ALL.ISRN hematology · 2011Article
- Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.PloS one · 2009Article
- Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.Genes & development · 2009Article
- Identification of novel Notch target genes in T cell leukaemia.Molecular cancer · 2009Article
- A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.Cancer research · 2009Article
- Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.The Journal of experimental medicine · 2008Article
- Review
- Notch signaling in leukemia.Annual review of pathology · 2008Review
- IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.The Journal of clinical investigation · 2007Article
- Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.Blood · 2007Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch and basic helix-loop-helix E2A pathways specify cell fate and regulate neoplastic transformation in a variety of cell types. Whereas Notch enhances tumorigenesis, E2A suppresses it. However, whether and how Notch and E2A interact functionally in an integrative mechanism for regulating neoplastic transformation remains to be understood. It has been shown that Notch3-induced T-cell leukaemia is abrogated by the inactivation of pTalpha/pre-T-cell antigen receptor (pre-TCR). We report here that Notch3-induced transcriptional activation of pTalpha/pre-TCR is responsible for the downregulation of E2A DNA binding and transcriptional activity. Further, the E2A messenger RNA and protein levels remain unaltered but the E2A inhibitor Id1 expression is augmented in thymocytes and T lymphoma cells derived from Notch3 transgenic mice. The increase in Id1 expression is achieved by pre-TCR-induced extracellular-signalling-regulated kinase 1/2. These observations support a model in which the upregulation of pre-TCR signalling seems to be the prerequi-site for Notch3-induced inhibition of E2A, thus leading to the development of lymphoma in Notch3 transgenic mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.