ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2003
Cellular distribution of NDRG1 protein in the rat kidney and brain during normal postnatal development.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Biomimetic fractal topography enhances podocyte maturation in vitro.Nature communications · 2025Article
- Reversing oncogenic transformation with iron chelation.Oncotarget · 2021Review
- Nervous NDRGs: the N-myc downstream-regulated gene family in the central and peripheral nervous system.Neurogenetics · 2019Review
- Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.Journal of the American Society of Nephrology : JASN · 2017Article
- Differentially expressed proteins underlying childhood cortical dysplasia with epilepsy identified by iTRAQ proteomic profiling.PloS one · 2017Article
- Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.Scientific reports · 2016Article
- Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells.World journal of clinical oncology · 2012Article
- Increased NDRG1 expression is associated with advanced T stages and poor vascularization in non-small cell lung cancer.Pathology oncology research : POR · 2012Article
- N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer.Pathology oncology research : POR · 2011Article
- Nuclear expression of N-myc downstream regulated gene 1/Ca(2+)-associated protein 43 is closely correlated with tumor angiogenesis and poor survival in patients with gastric cancer.Experimental and therapeutic medicine · 2011Article
- Differential expression patterns of NDRG family proteins in the central nervous system.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.Molecular and cellular biology · 2004Article
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6 authors.
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Abstract
N-myc downregulated gene 1 (NDRG1) is a 43-kD protein whose mRNA is induced by DNA damage, hypoxia, or prolonged elevation of intracellular calcium. Although NDRG1 is also upregulated during cell differentiation, there are few studies on NDRG1 expression during postnatal development. Here we investigated the expression and cellular distribution of NDRG1 protein in rat kidney and brain during postnatal development. Immunohistochemical analysis revealed that the cellular localization of NDRG1 protein in the kidney changed from the proximal convoluted tubules to the collecting ducts between postnatal days 10 and 20. In the brain, a change in cellular expression was also found from the hippocampal pyramidal neurons to the astrocytes in the gray matter during the same postnatal period. These alterations in the cellular distribution of NDRG1 were associated with shifts in the molecular assembly on Western blots. Under non-reduced conditions, the main NDRG1 band was found only around 215 kD in both kidney and brain during the early postnatal stage. After postnatal day 10, the immunoreactive bands shifted to 43 kD in the kidney and 129 kD in the brain. These changes in the cellular distribution and state of assembly may correlate with the functional maturation of both organs.
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