ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2003
Network organization of interstitial connective tissue cells in the human endolymphatic duct.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Hearing impairment in X-linked hypophosphatemia: a review.JBMR plus · 2025Article
- Article
- Endolymphatic duct and sac decompression: A new technique for Ménière's disease treatment.Surgical neurology international · 2022Article
- Claudin expression in the rat endolymphatic duct and sac - first insights into regulation of the paracellular barrier by vasopressin.Scientific reports · 2017Article
- The periductal channels of the endolymphatic duct, hydrodynamic implications.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Article
- An interstitial network of podoplanin-expressing cells in the human endolymphatic duct.Journal of the Association for Research in Otolaryngology : JARO · 2006Article
- Treatment of ear and bone disease in the Phex mouse mutant with dietary supplementation.American journal of otolaryngologyArticle
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human endolymphatic duct (ED) and sac of the inner ear have been suggested to control endolymph volume and pressure. However, the physiological mechanisms for these processes remain obscure. We investigated the organization of the periductal interstitial connective tissue cells and extracellular matrix (ECM) in four freshly fixed human EDs by transmission electron microscopy and by immunohistochemistry. The unique surgical material allowed a greatly improved structural and epitopic preservation of tissue. Periductal connective tissue cells formed frequent intercellular contacts and focally occurring electron-dense contacts to ECM structures, creating a complex tissue network. The connective tissue cells also formed contacts with the basal lamina of the ED epithelium and the bone matrix, connecting the ED with the surrounding bone of the vestibular aqueduct. The interstitial connective tissue cells were non-endothelial and non-smooth muscle fibroblastoid cells. We suggest that the ED tissue network forms a functional mechanical entity that takes part in the control of inner ear fluid pressure and endolymph resorption.
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