ArticleThe Journal of physiology2003
Properties of pacemaker potentials recorded from myenteric interstitial cells of Cajal distributed in the mouse small intestine.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ELECTROGASTROGRAPHY IN PEDIATRIC GASTROPARESIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos de gastroenterologia · 2025Pooled it
- Electrogastrography in Adult Gastroparesis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2025Pooled it
- CaPhysiological reviews · 2024Review
- Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).Handbook of experimental pharmacology · 2024Article
- Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro.Scientific reports · 2022Article
- Insights on gastrointestinal motility through the use of optogenetic sensors and actuators.The Journal of physiology · 2022Review
- CaCell calcium · 2021Article
- Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.Communications biology · 2021Article
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter.Neurogastroenterology and motility · 2020Article
- A Close Relationship Between Networks of Interstitial Cells of Cajal and Gastrointestinal TransitFrontiers in pharmacology · 2020Article
- NaFrontiers in physiology · 2020Article
- Synchrony of spontaneous CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Review
- CaThe Journal of physiology · 2019Article
- Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility.The Journal of physiology · 2019Article
- Smooth muscle atrophy and colon pathology in SMN deficient mice.American journal of translational research · 2019Article
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- Uterine EMG activity in the non-pregnant sow during estrous cycle.BMC veterinary research · 2018Article
- The effects of mitochondrial inhibitors on CaCell calcium · 2018Article
- Identification and Distribution of the Interstitial Cells of Cajal in the Abomasum of Goats.Cell transplantation · 2018Article
21 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recording of electrical responses from isolated small intestine of mice using conventional microelectrodes revealed two types of potential, a pacemaker potential and a slow wave, both with rapid rising primary components and following plateau components. The rate of rise and peak amplitude were greater for pacemaker potentials than for slow waves, and the plateau component was smaller in slow waves than in pacemaker potentials. Both potentials oscillated at a similar frequency (20-30 min-1). Unitary potentials often discharged during the interval between pacemaker potentials. Infusion of Lucifer Yellow allowed visualization of the recorded cells; pacemaker potentials were recorded from myenteric interstitial cells of Cajal (ICC-MY) while slow waves were recorded from circular smooth muscle cells. Pacemaker potentials were characterized as follows: the primary component was inhibited by Ni2+, Ca2+-free solution or depolarization with high-K+ solution, the plateau component was inhibited by 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS), an inhibitor of Ca2+-activated Cl- channels, low [Cl-]o solution or Ca2+-free solution, and the generation of potentials was abolished by co-application of Ni2+and DIDS or by chelating intracellular Ca2+ with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester (BAPTA-AM). These results indicate that in the mouse small intestine ICC-MY generate pacemaker potentials with two components in situ; the primary and plateau components may be generated by activation of voltage-dependent Ca2+-permeable channels and Ca2+-activated Cl- channels, respectively. Slow waves are generated in circular smooth muscles via electrotonic spread of pacemaker potentials. These properties of intestinal pacemaker potentials are considered essentially similar to those of gastric pacemaker potentials.
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