ArticleMolecular biology of the cell2003
The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- A chemically induced attenuated strain ofeLife · 2024Article
- Development and Use of a Monoclonal Antibody Specific for theFrontiers in cellular and infection microbiology · 2022Article
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Sexual reproduction of human fungal pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Roles of Cch1 and Mid1 in morphogenesis, oxidative stress response and virulence in Candida albicans.Mycopathologia · 2012Article
- The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence.Interdisciplinary perspectives on infectious diseases · 2011Article
- Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways.PLoS biology · 2010Article
- Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans.Eukaryotic cell · 2009Article
- Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.PLoS pathogens · 2009Article
- Conserved WCPL and CX4C domains mediate several mating adhesin interactions in Saccharomyces cerevisiae.Genetics · 2009Article
- Candida albicans cell wall proteins.Microbiology and molecular biology reviews : MMBR · 2008Review
- Complementary adhesin function in C. albicans biofilm formation.Current biology : CB · 2008Article
- Function of Candida albicans adhesin Hwp1 in biofilm formation.Eukaryotic cell · 2006Article
- Opaque cells signal white cells to form biofilms in Candida albicans.The EMBO journal · 2006Article
- Adherence and blocking of Candida albicans to cultured vaginal epithelial cells: treatments to decrease adherence.Infectious diseases in obstetrics and gynecology · 2006Article
- Unique aspects of gene expression during Candida albicans mating and possible G(1) dependency.Eukaryotic cell · 2005Article
- Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus.Eukaryotic cell · 2004Article
- Alpha-pheromone-induced "shmooing" and gene regulation require white-opaque switching during Candida albicans mating.Eukaryotic cell · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The cell wall protein Hwp1 was originally demonstrated to be expressed exclusively in hyphae of Candida albicans and cross-linked to human epithelium by mammalian transglutaminase. Hwp1 is expressed on the walls of hyphae formed by a/alpha, a/a, and alpha/alpha cells. Hence, it is expressed on hyphae independently of mating type. However, Hwp1 is selectively expressed on the wall of conjugation tubes formed by a/a cells, but not alpha/alpha cells, in the mating process. This was demonstrated in all possible crosses between four unrelated natural a/a strains and four unrelated alpha/alpha strains. In zygotes, Hwp1 is restricted to that portion of the wall of the conjugation bridge contributed by the a/a parent cell. Hwp1 staining further revealed that the first daughter bud that emerges from the conjugation bridge does so from the a/a-contributed portion. Hwp1 expression and localization during the mating process is, therefore, mating type specific, opaque phase specific, and alpha-pheromone induced. These results indicate that the mating type-specific contributions to the conjugation bridge during the mating process in C. albicans are qualitatively and functionally distinct and that the a/a portion of the bridge, which selectively contains Hwp1, bears the first daughter cell in the mating process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.