ArticleMolecular biology of the cell2004
Myosin-Va binds to and mechanochemically couples microtubules to actin filaments.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice.Nature communications · 2021Article
- Anterograde Axonal Transport in Neuronal Homeostasis and Disease.Frontiers in molecular neuroscience · 2020Review
- Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling.International journal of molecular sciences · 2019Review
- Defects in Axonal Transport in Inherited Neuropathies.Journal of neuromuscular diseases · 2019Review
- Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Myosin Va plays essential roles in maintaining normal mitosis, enhancing tumor cell motility and viability.Oncotarget · 2017Article
- Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.Molecular biology of the cell · 2014Article
- Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration.The Journal of investigative dermatology · 2014Article
- BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.Oxidative medicine and cellular longevity · 2014Article
- Article
- Axonal transport deficits and neurodegenerative diseases.Nature reviews. Neuroscience · 2013Review
- A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 in neurons.PloS one · 2013Article
- A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.Disease models & mechanisms · 2013Article
- Myosin Va is required for P body but not stress granule formation.The Journal of biological chemistry · 2011Article
- Article
- Unconventional myosins acting unconventionally.Trends in cell biology · 2009Review
- Control of granule mobility and exocytosis by Ca2+ -dependent formation of F-actin in pancreatic duct epithelial cells.Traffic (Copenhagen, Denmark) · 2009Article
- Myosin V and Kinesin act as tethers to enhance each others' processivity.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Slip sliding away with myosin V.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Myosin Va maneuvers through actin intersections and diffuses along microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Myosin-Va was identified as a microtubule binding protein by cosedimentation analysis in the presence of microtubules. Native myosin-Va purified from chick brain, as well as the expressed globular tail domain of this myosin, but not head domain bound to microtubule-associated protein-free microtubules. Binding of myosin-Va to microtubules was saturable and of moderately high affinity (approximately 1:24 Myosin-Va:tubulin; Kd = 70 nM). Myosin-Va may bind to microtubules via its tail domain because microtubule-bound myosin-Va retained the ability to bind actin filaments resulting in the formation of cross-linked gels of microtubules and actin, as assessed by fluorescence and electron microscopy. In low Ca2+, ATP addition induced dissolution of these gels, but not release of myosin-Va from MTs. However, in 10 microM Ca2+, ATP addition resulted in the contraction of the gels into aster-like arrays. These results demonstrate that myosin-Va is a microtubule binding protein that cross-links and mechanochemically couples microtubules to actin filaments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.