ArticleJournal of bacteriology2003
Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
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- In-Depth Proteome Coverage of In Vitro-CulturedJournal of proteome research · 2024Article
- Evaluation of whole-genome enrichment and sequencing ofiScience · 2024Article
- Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection.Scientific reports · 2023Article
- Longitudinal Variations in theMicrobiology spectrum · 2023Article
- Genetic Profiling of the Full-LengthMicrobiology spectrum · 2023Article
- Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis.PLoS pathogens · 2023Article
- Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.PLoS neglected tropical diseases · 2021Article
- Article
- Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol.BMC infectious diseases · 2020Article
- Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.PLoS neglected tropical diseases · 2020Article
- The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.BMC genomics · 2020Article
- Article
- Successful isolation of Treponema pallidum strains from patients' cryopreserved ulcer exudate using the rabbit model.PloS one · 2020Article
- Insights into the genetic variation profile of tprK in Treponema pallidum during the development of natural human syphilis infection.PLoS neglected tropical diseases · 2019Article
- Article
- Profile of the tprK gene in primary syphilis patients based on next-generation sequencing.PLoS neglected tropical diseases · 2019Article
- Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes.PLoS neglected tropical diseases · 2018Article
- Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.PLoS neglected tropical diseases · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
The tprK gene of Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, belongs to a 12-member gene family and encodes a protein with a predicted cleavable signal sequence and predicted transmembrane domains. Except for the Nichols type strain, all rabbit-propagated isolates of T. pallidum examined thus far are comprised of mixed populations of organisms with heterogeneous tprK sequences. We show that tprK sequences in treponemes obtained directly from syphilis patients are also heterogeneous. Clustering analysis demonstrates that primary chancre tprK sequences are more likely to cluster within a sample than among samples and that tighter clustering is seen within chancre samples than within rabbit-propagated isolates. Closer analysis of tprK sequences from a rabbit-propagated isolate reveals that individual variable regions have different levels of diversity, suggesting that variable regions may have different intrinsic rates of sequence change or may be under different levels of selection. Most variable regions show increased sequence diversity upon passage. We speculate that the diversification of tprK during infection allows organisms to evade the host immune response, contributing to reinfection and persistent infection.
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