ArticleWorld journal of gastroenterology2003
Liver cell adenoma with malignant transformation: a case report.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma.Cancer medicine · 2025Pooled it
- Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010Pooled it
- A Review of Incidence and Related Risk Factors in the Development of Hepatocellular Carcinoma.Cureus · 2023Review
- Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report.Surgical case reports · 2020Article
- Malignant transformation of hepatocellular adenoma: report of a case.The Pan African medical journal · 2020Article
- Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males.Internal medicine (Tokyo, Japan) · 2019Article
- Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report.Molecular and clinical oncology · 2016Article
- Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers.Chinese journal of cancer · 2015Article
- β-Catenin activated hepatocellular adenoma: a report of three cases in Korea.Gut and liver · 2014Article
- Non-viral factors contributing to hepatocellular carcinoma.World journal of hepatology · 2013Article
- Non-viral causes of hepatocellular carcinoma.World journal of gastroenterology · 2010Review
- A hepatocellular neoplasm accompanied with massive histiocyte infiltration.Clinical journal of gastroenterology · 2010Article
- A case of hepatocellular carcinoma within hepatocellular adenoma in a non-cirrhotic male.The Korean journal of internal medicine · 2009Review
- Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.World journal of gastroenterology · 2009Article
- Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance.Human pathology · 2008Article
- Simultaneous resection of liver cell adenomas and an intrahepatic portosystemic venous shunt with elevation of serum PIVKA-II level.Journal of gastroenterology · 2006Article
- [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma].Der Pathologe · 2006Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 57-year-old woman was referred to our hospital because of a liver mass detected by computed tomography. She had taken oral contraceptives for only one month at the age of thirty. Physical examination revealed no abnormalities, and laboratory data, including hepatic function tests, were within the normal range, with the exception of elevated levels of those serum proteins induced by the absence of vitamin K or by raised levels of the antagonist (PIVKA)-II (3,502 AU/ml). Abdominal ultrasonography revealed a hyperechoic mass measuring 10 X 10 cm in the left posterior segment of the liver. Because hepatocellular carcinoma could not be completely excluded, this mass was resected. The tumor consisted of sheets of uniform cells with clear cytoplasm, perinuclear eosinophilic granules and round nuclei. These histological findings were consistent with liver cell adenoma. Background hepatic tissue appeared normal. After resection of the tumor, serum PIVKA-II fell to within the normal range. An area of hepatocellular carcinoma (HCC) with a mid-trabecular pattern was immunohistochemically found, which was positive for PIVKA-II. Sinusoidal endothelial cells were CD34-positive, containing scattered PIVKA-II positive cells. This tumor was therefore finally diagnosed as liver cell adenoma with focal malignant transformation to HCC.
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