ArticleInternational journal of impotence research2003
Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.
Article in International journal of impotence research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- A visualization system for erectile vascular dynamics.Frontiers in cell and developmental biology · 2022Article
- Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells.Frontiers in pharmacology · 2022Review
- Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review.Frontiers in pharmacology · 2020Review
- The Effect of Alcohol Administration on the Corpus Cavernosum.The world journal of men's health · 2017Article
- Erectile dysfunction.Nature reviews. Disease primers · 2016Review
- The potent relaxant effect of resveratrol in rat corpus cavernosum and its underlying mechanisms.International journal of impotence research · 2013Article
- Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves.British journal of pharmacology · 2012Article
- Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.Neurochemical research · 2009Article
- In vitro models: research in physiology and pharmacology of the lower urinary tract.British journal of pharmacology · 2006Review
- Establishment of mouse line showing inducible priapism-like phenotypes.Reproductive medicine and biologyArticle
- Gene and protein expression profiles of prostaglandin E2 receptor subtypes in the human corpus cavernosum.International journal of impotence researchArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In this study, we have characterized functional EP receptors in human corpus cavernosum (HCC) tissue and in HCC smooth muscle cells (SMC). Using RNase protection assays, we determined expression of EP2, EP3I and EP3II receptor mRNA. In organ bath preparations of HCC tissue strips, PGE1 caused dose-dependent relaxation at concentrations below 300 nM. At concentrations greater than 300 nM, PGE1 caused contraction. Addition of the EP1/EP2/EP3 receptor antagonist AH6809 inhibited this contraction and facilitated further relaxation through concentrations above 1 microM of PGE1. The EP1/EP3 receptor selective agonist 17-phenyltrinor-PGE2 caused dose-dependent contraction that was partially attenuated by SC51322, an EP1 selective antagonist. In cultures of HCC SMC, PGE1 stimulated cAMP accumulation in a dose-dependent manner. Interestingly, AH6809 significantly attenuated PGE1-induced cAMP accumulation. Sulprostone, a selective EP3 receptor agonist, induced weak contractions in HCC tissue strips but augmented forskolin-induced cAMP synthesis in HCC SMC. The data in this study suggest that HCC and cultured smooth muscle cells express EP1, EP2 and EP3 receptors. These receptors mediate their responses via different biochemical pathways and are expected to have different responses in regulating smooth muscle tone. Thus, we suggest that the ultimate response in erectile tissue to various prostanoids is the integration of responses elicited by individual EP receptor subtypes to a given ligand.
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