ArticleOncogene2003
Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Cumulative Evidence for Relationships Between Multiple Variants in the TERT and CLPTM1L Region and Risk of Cancer and Non-Cancer Disease.Frontiers in oncology · 2022Pooled it
- TERT genetic polymorphism rs2736100 was associated with lung cancer: a meta-analysis based on 14,492 subjects.Genetic testing and molecular biomarkers · 2013Pooled it
- MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.PloS one · 2013Pooled it
- Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.Journal of the National Cancer Institute · 2012Pooled it
- Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus.medRxiv : the preprint server for health sciences · 2026Article
- Association of hTERT MNS16A polymorphism with clinical outcomes of North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant.Scientific reports · 2024Article
- Analysis of MNS16A VNTR polymorphic sequence variations of theCurrent urology · 2021Article
- Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differences.Nucleic acids research · 2021Article
- TERT-Regulation and Roles in Cancer Formation.Frontiers in immunology · 2020Review
- The MNS16A VNTR polymorphism of the TERT gene in bladder cancer.Turkish journal of urology · 2020Article
- Analysis of the Association BetweenGenes · 2019Article
- Variability within the humanOncoTargets and therapy · 2019Article
- MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer.Oncotarget · 2017Article
- Review
- hTERT gene polymorphism correlates with the risk and the prognosis of thyroid cancer.Cancer biomarkers : section A of Disease markers · 2016Article
- Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12.Movement disorders : official journal of the Movement Disorder Society · 2015Article
- Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population.BMC research notes · 2014Article
- Genome maintenance and human longevity.Current opinion in genetics & development · 2014Review
- HTERT MNS16A polymorphism in breast cancer: a case-control study.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown to play an important role in one's risk of developing lung cancer. We report here the identification of a polymorphic tandem repeats minisatellite (termed MNS16A) in the downstream region of the human telomerase gene. This minisatellite is located upstream of an antisense transcript from the human telomerase gene locus and was demonstrated to have promoter activity. The promoter activity was significantly lower in the construct containing the shorter repeats, suggesting that the MNS16A variant may have a relevance of functionality. To explore the role of this novel polymorphism in lung cancer, we conducted a pilot hospital-based case-control study by identifying the MNS16A genotype with genomic DNA from 53 lung cancer patients and 72 cancer-free controls. We found four different alleles and classified them as shorter (S) or longer (L) on the functional basis of the length of the repeats in the controls. The MNS16A genotype distributions of the SS, SL, and LL genotypes were 11, 32, and 57%, respectively, in the cases, and 14, 40, and 46%, respectively, in the controls. Compared with the SS+SL genotype, the LL genotype was associated with greater than twofold increased risk of lung cancer (odds ratio=2.18; 95% confidence interval=0.92, 5.20) after adjustment for age, sex, ethnicity, and smoking status, suggesting a potential role of MNS16A in lung cancer susceptibility. Larger studies are needed to verify our findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.