ArticleBritish journal of cancer2003
Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival.Scientific reports · 2025Article
- Genomic Analysis of Lymphoma Risk in Bullmastiff Dogs.Veterinary sciences · 2023Article
- Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis.Veterinary sciences · 2023Article
- Environmental risk factors for the development of oral squamous cell carcinoma in cats.Journal of veterinary internal medicine · 2022Article
- Article
- Clinical Cytogenetics of the Dog: A Review.Animals : an open access journal from MDPI · 2021Review
- The Role of Bcl-xL Protein Research in Veterinary Oncology.International journal of molecular sciences · 2020Review
- The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma.Frontiers in oncology · 2020Review
- Comprehensive Genomic Profiling of Androgen-Receptor-Negative Canine Prostate Cancer.International journal of molecular sciences · 2019Article
- Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours.Journal of applied genetics · 2019Article
- Clonality testing in the lymph nodes from dogs with lymphadenomegaly due to Leishmania infantum infection.PloS one · 2019Article
- Demographic history, selection and functional diversity of the canine genome.Nature reviews. Genetics · 2017Review
- Hematoporphyrin monomethyl ether combined with He-Ne laser irradiation-induced apoptosis in canine breast cancer cells through the mitochondrial pathway.Journal of veterinary science · 2016Article
- Canine Lymphoma, More Than a Morphological Diagnosis: What We Have Learned about Diffuse Large B-Cell Lymphoma.Frontiers in veterinary science · 2016Review
- Canine urothelial carcinoma: genomically aberrant and comparatively relevant.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health.The AAPS journal · 2015Review
- Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State.Bioinformatics and biology insights · 2015Article
- Onco-epidemiology of domestic animals and targeted therapeutic attempts: perspectives on human oncology.Journal of cancer research and clinical oncology · 2014Review
- Genome aberrations in canine mammary carcinomas and their detection in cell-free plasma DNA.PloS one · 2013Article
- Breed-predispositions to cancer in pedigree dogs.ISRN veterinary science · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
Recurrent chromosome aberrations are frequently observed in human neoplastic cells and often correlate with other clinical and histopathological parameters of a given tumour type. The clinical presentation, histology and biology of many canine cancers closely parallels those of human malignancies. Since humans and dogs demonstrate extensive genome homology and share the same environment, it is expected that many canine cancers will also be associated with recurrent chromosome aberrations. To investigate this, we have performed molecular cytogenetic analyses on 25 cases of canine multicentric lymphoma. Comparative genomic hybridisation analysis demonstrated between one and 12 separate regions of chromosomal gain or loss within each case, involving 32 of the 38 canine autosomes. Genomic gains were almost twice as common as losses. Gain of dog chromosome (CFA) 13 was the most common aberration observed (12 of 25 cases), followed by gain of CFA 31 (eight cases) and loss of CFA 14 (five cases). Cytogenetic and histopathological data for each case are presented, and cytogenetic similarities with human non-Hodgkin's lymphoma are discussed. We have also assembled a panel of 41 canine chromosome-specific BAC probes that may be used for accurate and efficient chromosome identification in future studies of this nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.