ArticleBritish journal of cancer2003
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis.Cancer cell international · 2021Review
- Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms.Journal of hematology & oncology · 2019Review
- ATM in breast and brain tumors: a comprehensive review.Cancer biology & medicine · 2018Article
- Ataxia-telangiectasia gene (Current oncology (Toronto, Ont.) · 2018Review
- The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia.The Journal of biological chemistry · 2016Article
- Genomic Biomarkers for Breast Cancer Risk.Advances in experimental medicine and biology · 2016Review
- Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia.British journal of cancer · 2012Article
- Genome-wide association studies of cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- Low levels of ATM in breast cancer patients with clinical radiosensitivity.Genome integrity · 2010Article
- Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.Clinical chemistry · 2009Article
- Variants in the ATM gene and breast cancer susceptibility.Genome medicine · 2009Article
- Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.Human mutation · 2009Article
- A hypothesis-generating search for new genetic breast cancer syndromes--a national study in 803 Swedish families.Hereditary cancer in clinical practice · 2007Article
- ATM and breast cancer susceptibility.Oncogene · 2006Review
- Models of genetic susceptibility to breast cancer.Oncogene · 2006Review
- Radiation and breast cancer: a review of current evidence.Breast cancer research : BCR · 2005Review
- Article
- ATM and genome maintenance: defining its role in breast cancer susceptibility.Journal of mammary gland biology and neoplasia · 2004Review
- Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.Breast cancer research : BCR · 2004Article
- Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.Breast cancer research : BCR · 2004Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Recent reports suggest that two ATM gene mutations, 7271T>G and IVS10-6T>G, are associated with a high risk of breast cancer among multiple-case families. To assess the importance of these two mutations in another 'high-risk' group, young women (under age 51) with multiple primaries, we screened a large population-based series of young women with bilateral breast cancer and compared the frequency of these mutations among similar women diagnosed with unilateral breast cancer. The 1149 women included were enrolled in an ongoing population-based case-control study of the genetic factors that contribute to bilateral breast cancer; they were not selected on the basis of family history of cancer. Screening for 7271T>G and IVS10-6T>G ATM gene mutations was conducted using DHPLC followed by direct sequencing. The 7271T>G mutation was detected in one out of 638 (0.2%) women with unilateral breast cancer and in none of the bilateral cases, and the IVS10-6T>G mutation in one out of 511 (0.2%) bilateral and in eight out of 638 (1.3%) unilateral breast cancer cases. Carriers of either mutation were not limited to women with a family history. Given the likelihood that young women with bilateral breast cancer have a genetic predisposition, the observed mutation distribution is contrary to that expected if these two mutations were to play an important role in breast carcinogenesis among individuals at high risk.
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