ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Adrenergic Modulation of Acetylcholine Release at the Mouse Neuromuscular Junctions of Fast-Twitch Skeletal Muscle.Neurochemical research · 2025Review
- Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions.Journal of neurophysiology · 2023Article
- Sensorimotor Perturbation Induces Late and Transient Molecular Synaptic Proteins Activation and Expression Changes.Journal of molecular neuroscience : MN · 2021Article
- Review
- Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome.Human molecular genetics · 2019Article
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Importance of Full-Collapse Vesicle Exocytosis for Synaptic Fatigue-Resistance at Rat Fast and Slow Muscle Neuromuscular Junctions.International journal of molecular sciences · 2018Article
- Morphological and functional changes in innervation of a fast forelimb muscle in SOD1-G85R mice.Neurobiology of disease · 2012Article
- Respiratory muscle plasticity.Comprehensive Physiology · 2012Review
- Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.Respiratory physiology & neurobiology · 2012Article
- TGF-beta2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- In vivo long-term synaptic plasticity of glial cells.The Journal of physiology · 2010Article
- Neuromuscular adaptations to respiratory muscle inactivity.Respiratory physiology & neurobiology · 2009Review
- The role of cGMP-dependent signaling pathway in synaptic vesicle cycle at the frog motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy.The Journal of clinical investigation · 2008Article
- Heterogeneity in synaptic vesicle release at neuromuscular synapses of mice expressing synaptopHluorin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- De-phosphorylation of MyoD is linking nerve-evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle.The Journal of physiology · 2007Article
- Synaptic vesicle recycling adapts to chronic changes in activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Long-term in vivo modulation of synaptic efficacy at the neuromuscular junction of Rana pipiens frogs.The Journal of physiology · 2005Article
- "Fast" and "slow" muscle fibres in hindlimb muscles of adult rats regenerate from intrinsically different satellite cells.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuromuscular junctions (NMJs) on fast and slow muscle fibers display different transmitter release characteristics that appear well adapted to the different patterns of nerve impulses that they transmit in vivo. Here, we ask whether the release properties of such NMJs, termed fast and slow, can be transformed by chronic nerve stimulation. In young adult rats, nerve impulse conduction in the sciatic nerve was blocked by TTX, and the nerve to the fast extensor digitorum longus (EDL) or the slow soleus (SOL) muscle stimulated directly below the block with slow (20 Hz for 10 sec every 30 sec) or fast (150 Hz for 1 sec every 60 sec) stimulus patterns, respectively. After 3-4 weeks, originally fast EDL-NMJs and slow SOL-NMJs had become almost fully transformed to slow and fast NMJs, respectively, with respect to maintenance of transmitter release during tonic 20 Hz stimulation in vitro and ratio of quantal content to vesicle pool size. TTX block alone had no such transforming effect. Vesicle recycle time was unaffected by the stimulation, whereas initial quantal content and vesicle pool size were reduced (by 49% and 57% in EDL and 33% and 67% in SOL). Muscle fiber diameter also declined (by 49% in EDL and 33% in SOL vs 46% in unstimulated SOL; unstimulated EDL was not examined). We conclude that fast and slow NMJs display marked plasticity by being able to adapt important release characteristics to the impulse patterns imposed on them.
Indexed as
Identifiers
14561861PMC6740572W2145216601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.