ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Suppression of adult neurogenesis impairs olfactory learning and memory in an adult insect.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
- The brain of the female Anopheles gambiae mosquito at spatial and single-cell resolution.Nature communications · 2026Article
- Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan.GeroScience · 2026Article
- The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.Research square · 2026Article
- Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies.GeroScience · 2025Article
- Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Adult neurogenesis does not explain the extensive post-eclosion growth ofRoyal Society open science · 2023Article
- Article
- Poor adult nutrition impairs learning and memory in a parasitoid wasp.Scientific reports · 2021Article
- Ecological Stoichiometry of Bumblebee Castes, Sexes, and Age Groups.Frontiers in physiology · 2021Article
- Differences in behavior between surface and cave Astyanax mexicanus may be mediated by changes in catecholamine signaling.The Journal of comparative neurology · 2020Article
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- Adult neurogenesis in the mushroom bodies of red flour beetles (Tribolium castaneum, HERBST) is influenced by the olfactory environment.Scientific reports · 2020Article
- A Cold-Blooded View on Adult Neurogenesis.Frontiers in neuroscience · 2017Review
- Roles of OA1 octopamine receptor and Dop1 dopamine receptor in mediating appetitive and aversive reinforcement revealed by RNAi studies.Scientific reports · 2016Article
- Temporal features of adult neurogenesis: differences and similarities across mammalian species.Frontiers in neuroscience · 2013Article
- Roles of aminergic neurons in formation and recall of associative memory in crickets.Frontiers in behavioral neuroscience · 2010Article
- Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.PloS one · 2009Article
- Roles of octopaminergic and dopaminergic neurons in appetitive and aversive memory recall in an insect.BMC biology · 2009Article
- Agonistic behavior enhances adult neurogenesis in male Acheta domesticus crickets.The Journal of experimental biology · 2009Article
- Cell proliferation in the Drosophila adult brain revealed by clonal analysis and bromodeoxyuridine labelling.Neural development · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although adult neurogenesis has now been demonstrated in many different species, the functional role of newborn neurons still remains unclear. In the house cricket, a cluster of neuroblasts, located in the main associative center of the insect brain, keeps producing new interneurons throughout the animal's life. Here we address the functional significance of adult neurogenesis by specific suppression of neuroblast proliferation using gamma irradiation of the insect's head and by examining the impact on the insect's learning ability. Forty gray irradiation performed on the first day of adult life massively suppressed neuroblasts and their progeny without inducing any noticeable side effect. We developed a new operant conditioning paradigm especially designed for crickets: the "escape paradigm." Using olfactory cues, visual cues, or both, crickets had to choose between two holes, one allowing them to escape and the other leading to a trap. Crickets lacking adult neurogenesis exhibited delayed learning when olfactory cues alone were used. Furthermore, retention 24 hr after conditioning was strongly impaired in irradiated crickets. By contrast, when visual cues instead of olfactory ones were provided, performance of irradiated insects was only slightly affected; when both olfactory and visual cues were present, their performance was not different from that of controls. From these results, it can be postulated that newborn neurons participate in the processing of olfactory information required for complex operant conditioning.
Indexed as
Identifiers
14561855PMC6740575W1899621519What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.