ArticleThe Journal of physiology2003
Substance P presynaptically depresses the transmission of sensory input to bronchopulmonary neurons in the guinea pig nucleus tractus solitarii.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Bradykinin sensitizes the cough reflex via a BRespiratory research · 2019Article
- Dedicated C-fibre viscerosensory pathways to central nucleus of the amygdala.The Journal of physiology · 2017Article
- Plasticity of vagal afferent signaling in the gut.Medicina (Kaunas, Lithuania) · 2017Review
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Investigation of Neurokinin-1 Receptor Antagonism as a Novel Treatment for Chronic Bronchitis in Dogs.Journal of veterinary internal medicine · 2016Article
- Putative roles of neuropeptides in vagal afferent signaling.Physiology & behavior · 2014Review
- Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats.Physiological reports · 2013Article
- Independent transmission of convergent visceral primary afferents in the solitary tract nucleus.Journal of neurophysiology · 2013Article
- The unsilent majority-TRPV1 drives "spontaneous" transmission of unmyelinated primary afferents within cardiorespiratory NTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Workshop: tuning the 'cough center'.Pulmonary pharmacology & therapeutics · 2011Article
- Central mechanisms II: pharmacology of brainstem pathways.Handbook of experimental pharmacology · 2009Review
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.Handbook of experimental pharmacology · 2009Review
- Plasticity in glutamatergic NTS neurotransmission.Respiratory physiology & neurobiology · 2008Review
- Comparison of baroreceptive to other afferent synaptic transmission to the medial solitary tract nucleus.American journal of physiology. Heart and circulatory physiology · 2008Article
- Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius.Neuroscience · 2007Article
- Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Central pathways of pulmonary and lower airway vagal afferents.Journal of applied physiology (Bethesda, Md. : 1985) · 2006Review
- Vasopressin inhibits glutamate release via two distinct modes in the brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance P modulates the reflex regulation of respiratory function by its actions both peripherally and in the CNS, particularly in the nucleus tractus solitarii (NTS), the first central site for synaptic contact of the lung and airway afferent fibres. There is considerable evidence that the actions of substance P in the NTS augment respiratory reflex output, but the precise effects on synaptic transmission have not yet been determined. Therefore, we determined the effects of substance P on synaptic transmission at the first central synapses by using whole-cell voltage clamping in an NTS slice preparation. Studies were performed on second-order neurons in the slice anatomically identified as receiving monosynaptic input from sensory nerves in the lungs and airways. This was done by the fluorescent labelling of terminal boutons after 1,1'-dioctadecyl-3,3,3',3'-tetra-methylindocarbo-cyanine perchlorate (DiI) was applied via tracheal instillation. Substance P (1.0, 0.3 and 0.1 microM) significantly decreased the amplitude of excitatory postsynaptic currents (eEPSCs) evoked by stimulation of the tractus solitarius, in a concentration-dependent manner. The decrease was accompanied by an increase in the paired-pulse ratio of two consecutive eEPSCs, and a decrease in the frequency, but not the amplitude, of spontaneous EPSCs and miniature EPSCs, findings consistent with a presynaptic site of action. The effects were consistently and significantly attenuated by a neurokinin-1 (NK1) receptor antagonist (SR140333, 3 muM). The data suggest a new site of action for substance P in the NTS (NK1 receptors on the central terminals of sensory fibres) and a new mechanism (depression of synaptic transmission) for regulating respiratory reflex function.
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