ArticleAgents and actions1992
Hypoxia/reoxygenation stimulates endothelial cells to promote interleukin-1 and interleukin-6 production. Effects of free radical scavengers.
Article in Agents and actions, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 88 citations in OpenAlex.
- Acupuncture Combined with Hydrotherapy in Diabetes Patients with Mild Lower-Extremity Arterial Disease: A Prospective, Randomized, Nonblinded Clinical Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
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- Strategies to attenuate maladaptive inflammatory response associated with cardiopulmonary bypass.Frontiers in surgery · 2024Review
- Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea.BMC pulmonary medicine · 2022Article
- IL-6: Relevance for immunopathology of SARS-CoV-2.Cytokine & growth factor reviews · 2020Review
- Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy.The journal of pathology. Clinical research · 2019Article
- Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses.Scientific reports · 2018Article
- Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature.International journal of molecular sciences · 2017Review
- IL-1β and IL-18: inflammatory markers or mediators of hypertension?British journal of pharmacology · 2014Review
- Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extra-cellular signalling nexus?Cell stress & chaperones · 2013Article
- An evolving new paradigm: endothelial cells--conditional innate immune cells.Journal of hematology & oncology · 2013Review
- Determination of Interleukin-6 and Tumor Necrosis Factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia.BMC pregnancy and childbirth · 2005Article
- The overtraining syndrome in athletes: a stress-related disorder.Journal of endocrinological investigation · 2004Review
- Endothelial kinin B(1)-receptors are induced by myocardial ischaemia-reperfusion in the rabbit.The Journal of physiology · 2001Article
- Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells.British journal of pharmacology · 1999Article
- Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?Annals of surgery · 1996Review
- Effects of oxidative stress on expression of extracellular superoxide dismutase, CuZn-superoxide dismutase and Mn-superoxide dismutase in human dermal fibroblasts.The Biochemical journal · 1994Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular endothelium produces and/or interferes with various cytokines. Previous studies have demonstrated interactions of these inflammatory and immunological mediators with oxygen-derived free radicals. The present work examines the relationship between hypoxia/reoxygenation (H/R) and cytokine production by cultured endothelial cells. Human umbilical vein endothelial cell (HUVEC) monolayers were incubated for 24 h in normoxia or submitted to 5 h hypoxia/19 h reoxygenation. Then, interleukin-1 (IL-1) alpha and beta, and interleukin-6 (IL-6), were measured in culture supernatants by specific enzyme immunoassays and bioassays, respectively. Under these conditions, the spontaneous production of IL-1 and IL-6, detected in normoxic HUVEC, greatly increased after H/R treatment. The observed enhancement was cycloheximide-sensitive and, consequently, reflected a de novo protein synthesis. Superoxide dismutase and glutathione peroxidase prevented H/R-induced IL-1 and IL-6 increase. These results constitute the first demonstration that H/R stimulates HUVEC to promote IL-1 and IL-6 production and strongly suggest a role for oxygen-derived free radicals in the cytokine synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.