ArticleThe Journal of clinical investigation2003
A population of c-Kit(low)(CD45/TER119)- hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Functional characterization of CD49fJournal of molecular histology · 2022Article
- The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration.International journal of biological sciences · 2016Review
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells.Journal of cellular and molecular medicine · 2014Review
- The road to regenerative liver therapies: the triumphs, trials and tribulations.Biotechnology advances · 2013Review
- Cellular and molecular basis of liver development.Comprehensive Physiology · 2013Review
- Article
- Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinational and temporal adjustment of soluble factors.Biotechnology journal · 2012Article
- Growth factor- and cytokine-driven pathways governing liver stemness and differentiation.World journal of gastroenterology · 2010Article
- Stem cells in hepatocarcinogenesis: evidence from genomic data.Seminars in liver disease · 2010Review
- In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art.Stem cells (Dayton, Ohio) · 2009Review
- Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- An efficient method of sorting liver stem cells by using immuno-magnetic microbeads.World journal of gastroenterology · 2006Article
- Adult stem cells and cancer stem cells: tie in or tear apart?Journal of cancer research and clinical oncology · 2005Review
- Hepatocyte progenitors in man and in rodents--multiple pathways, multiple candidates.International journal of experimental pathology · 2005Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryo liver morphogenesis takes place after gastrulation and starts with a ventral foregut evagination that reacts to factor signaling from both cardiac mesoderm and septum transversum mesenchyme. Current knowledge of the progenitor stem cell populations involved in this early embryo liver development is scarce. We describe here a population of 11-day postcoitus c-Kit(low)(CD45/TER119)- liver progenitors that selectively expressed hepatospecific genes and proteins in vivo, was self-maintained in vitro by long-term proliferation, and simultaneously differentiated into functional hepatocytes and bile duct cells. Purified c-Kit(low)(CD45/TER119)- liver cells cocultured with cell-depleted fetal liver fragments engrafted and repopulated the hepatic cell compartments of the latter organoids, suggesting that they may include the embryonic stem cells responsible for liver development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.