ArticleDevelopment (Cambridge, England)2003
Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.
Article in Development (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed.
- Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish.Marine life science & technology · 2025Article
- Single-Cell Transcriptomic Analysis of the Potential Mechanisms of Follicular Development inInternational journal of molecular sciences · 2025Article
- How relevant is the mouse model for understanding human sex determination?International journal of biological sciences · 2025Article
- MAX controls meiotic entry in sexually undifferentiated germ cells.Scientific reports · 2024Article
- Cell cycle regulation for meiosis in mammalian germ cells.The Journal of reproduction and development · 2023Review
- Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse.Development (Cambridge, England) · 2023Article
- Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.Biology of reproduction · 2021Article
- Disorders of Sexual Development: Current Status and Progress in the Diagnostic Approach.Current urology · 2020Review
- WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.Reproduction (Cambridge, England) · 2019Review
- Retinoic Acid and Germ Cell Development in the Ovary and Testis.Biomolecules · 2019Review
- Gametogenesis: A journey from inception to conception.Current topics in developmental biology · 2019Review
- Germ cells in the teleost fish medaka have an inherent feminizing effect.PLoS genetics · 2018Article
- Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer.Cell reports · 2017Article
- Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nature reviews. Genetics · 2017Review
- Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.Journal of cell science · 2016Article
- ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries.Nature communications · 2016Article
- Effects of tamoxifen on autosomal genes regulating ovary maintenance in adult mice.Environmental science and pollution research international · 2015Article
- Meiotic wave adds extra asymmetry to the development of female chicken gonads.Molecular reproduction and development · 2015Article
- Cell fate commitment during mammalian sex determination.Current opinion in genetics & development · 2015Review
- Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The developmental fate of primordial germ cells in the mammalian gonad depends on their environment. In the XY gonad, Sry induces a cascade of molecular and cellular events leading to the organization of testis cords. Germ cells are sequestered inside testis cords by 12.5 dpc where they arrest in mitosis. If the testis pathway is not initiated, germ cells spontaneously enter meiosis by 13.5 dpc, and the gonad follows the ovarian fate. We have previously shown that some testis-specific events, such as mesonephric cell migration, can be experimentally induced into XX gonads prior to 12.5 dpc. However, after that time, XX gonads are resistant to the induction of cell migration. In current experiments, we provide evidence that this effect is dependent on XX germ cells rather than on XX somatic cells. We show that, although mesonephric cell migration cannot be induced into normal XX gonads at 14.5 dpc, it can be induced into XX gonads depleted of germ cells. We also show that when 14.5 dpc XX somatic cells are recombined with XY somatic cells, testis cord structures form normally; however, when XX germ cells are recombined with XY somatic cells, cord structures are disrupted. Sandwich culture experiments suggest that the inhibitory effect of XX germ cells is mediated through short-range interactions rather than through a long-range diffusible factor. The developmental stage at which XX germ cells show a disruptive effect on the male pathway is the stage at which meiosis is normally initiated, based on the immunodetection of meiotic markers. We suggest that at the stage when germ cells commit to meiosis, they reinforce ovarian fate by antagonizing the testis pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.