ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2003
Evolution of photosensory pineal organs in new light: the fate of neuroendocrine photoreceptors.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 148 citations in OpenAlex.
- The photoreceptive and neuroendocrine pineal organ of Atlantic salmon.Frontiers in physiology · 2026Article
- Evolution of Pineal Nonvisual Opsins in Lizards and the Tuatara and Identification of Lepidopsin: A New Opsin Gene.Genome biology and evolution · 2025Article
- Tumor heterogeneity in retinoblastoma: a literature review.Cancer metastasis reviews · 2025Review
- Histopathology and molecular pathology of pediatric pineal parenchymal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Cross-sectional analysis of potential risk factors of the pineal gland calcification.BMC endocrine disorders · 2023Article
- Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus.Frontiers in cell and developmental biology · 2022Article
- Characterization ofFrontiers in physiology · 2021Article
- Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.International journal of molecular sciences · 2020Review
- Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland.Journal of pineal research · 2020Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Pineal progenitors originate from a non-neural territory limited by FGF signalling.Development (Cambridge, England) · 2019Article
- Article
- The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish.BMC evolutionary biology · 2019Article
- Pineal gland dysfunction in Alzheimer's disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis.Molecular neurodegeneration · 2019Review
- Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish.Frontiers in endocrinology · 2019Review
- Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish.Communications biology · 2019Article
- The origins of the circumventricular organs.Journal of anatomy · 2018Review
- Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen's Four Questions.Molecules (Basel, Switzerland) · 2018Review
- Article
- Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.PLoS genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pineal evolution is envisaged as a gradual transformation of pinealocytes (a gradual regression of pinealocyte sensory capacity within a particular cell line), the so-called sensory cell line of the pineal organ. In most non-mammals the pineal organ is a directly photosensory organ, while the pineal organ of mammals (epiphysis cerebri) is a non-sensory neuroendocrine organ under photoperiod control. The phylogenetic transformation of the pineal organ is reflected in the morphology and physiology of the main parenchymal cell type, the pinealocyte. In anamniotes, pinealocytes with retinal cone photoreceptor-like characteristics predominate, whereas in sauropsids so-called rudimentary photoreceptors predominate. These have well-developed secretory characteristics, and have been interpreted as intermediaries between the anamniote pineal photoreceptors and the mammalian non-sensory pinealocytes. We have re-examined the original studies on which the gradual transformation hypothesis of pineal evolution is based, and found that the evidence for this model of pineal evolution is ambiguous. In the light of recent advances in the understanding of neural development mechanisms, we propose a new hypothesis of pineal evolution, in which the old notion 'gradual regression within the sensory cell line' should be replaced with 'changes in fate restriction within the neural lineage of the pineal field'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.