Evidence map›Paper›PMID 14561278›Full record

Trial reportProceedings. Biological sciences2003

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.

Caroline Rae, Alison L Digney, Sally R McEwan, Timothy C Bates

Registry-linked trialOpen access · greenAbstract readClinical TrialControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings. Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05562232 (The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol), which is not on this map. Cited by 92 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 7 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05562232 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol

TypeinterventionalSponsorPsychiatric Research Unit, Region Zealand, DenmarkRan2023 to 2024Enrolled45ConditionsMild Traumatic Brain Injury, Concussion, BrainArmsCreatine Monohydrate
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 7 syntheses or guidelines pooled it, 259 citations in OpenAlex.

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  5. Benefits of Creatine Supplementation for Vegetarians Compared to Omnivorous Athletes: A Systematic Review.International journal of environmental research and public health · 2020
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Caroline RaeDiscipline of Biochemistry, School of Molecular and Microbial Biosciences G08, The University of Sydney, Sydney, NSW 2006, Australia. c.rae@mmb.usyd.edu.au
Alison L Digney
Sally R McEwan
Timothy C Bates
University of Sydney · AUMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creatine supplementation is in widespread use to enhance sports-fitness performance, and has been trialled successfully in the treatment of neurological, neuromuscular and atherosclerotic disease. Creatine plays a pivotal role in brain energy homeostasis, being a temporal and spatial buffer for cytosolic and mitochondrial pools of the cellular energy currency, adenosine triphosphate and its regulator, adenosine diphosphate. In this work, we tested the hypothesis that oral creatine supplementation (5 g d(-1) for six weeks) would enhance intelligence test scores and working memory performance in 45 young adult, vegetarian subjects in a double-blind, placebo-controlled, cross-over design. Creatine supplementation had a significant positive effect (p < 0.0001) on both working memory (backward digit span) and intelligence (Raven's Advanced Progressive Matrices), both tasks that require speed of processing. These findings underline a dynamic and significant role of brain energy capacity in influencing brain performance.

Indexed as

Dietary SupplementsAdultBrain ChemistryCreatinineCross-Over StudiesDouble-Blind MethodFemaleHumansIntelligenceMaleMemoryCreatinine

Identifiers

PMID14561278
PMCPMC1691485
OpenAlexW2155476557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.