ArticleDigestive diseases and sciences2003
Oxygen consumption and chloride secretion in rat distal colon isolated mucosa.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Rectification of oxygen transfer through the rat colonic epithelium.World journal of gastrointestinal pathophysiology · 2017Article
- Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia.American journal of physiology. Cell physiology · 2015Review
- The effect of acute hypoxia on short-circuit current and epithelial resistivity in biopsies from human colon.Digestive diseases and sciences · 2013Article
- Electrogenic transport, oxygen consumption, and sensitivity to acute hypoxia of human colonic epithelium.International journal of colorectal disease · 2011Article
- Effects of chronic hypoxia on electrogenic transport and transport-related oxygen consumption in rat distal colon.Digestive diseases and sciences · 2008Article
- The effects of amiloride and age on oxygen consumption coupled to electrogenic sodium transport in the human sigmoid colon.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aerobic metabolic cost of chloride secretion was studied in rat distal colon isolated mucosa under several conditions by simultaneous measurement of short-circuit current and oxygen consumption under conditions that preserve vectorial ion transport. A low-chloride solution and the presence of bumetanide plus diphenylamine-2-carboxylate reduced short-circuit current by 75% and oxygen consumption by 25%. Ouabain decreased short-circuit current by 93% and oxygen consumption by 32%. Serotonin increased both variables by 59% and 33%, respectively. Bumetanide and diphenylamine-2-carboxylate reduced but did not abolish the effect of serotonin on short-circuit current and oxygen consumption. Changes in short-circuit current and oxygen consumption were linearly correlated under all conditions tested. It is concluded that, in the unstimulated rat distal colon epithelium, chloride secretion accounts for about 75% of ouabain-sensitive short-circuit current and oxygen consumption. Stimulated chloride secretion may demand over 40% of total oxygen consumption.
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Registered trials
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