ArticleDigestive diseases and sciences2003
Selection of patients with gastroesophageal reflux disease for antireflux surgery based on esophageal manometry.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Division of the short gastric vessels during laparoscopic Nissen fundoplication: clinical and functional outcome during long-term follow-up in a prospectively randomized trial.Surgical endoscopy · 2009Trial
- Proposed approach to the challenging management of progressive gastroesophageal reflux disease.World journal of gastrointestinal endoscopy · 2018Review
- Value of preoperative esophageal function studies before laparoscopic antireflux surgery.Surgical endoscopy · 2011Article
- Laparoscopic partial posterior (Toupet) fundoplication improves esophageal bolus propagation on scintigraphy.Surgical endoscopy · 2008Article
- The Nissen fundoplication: indication, technical aspects and postoperative outcome.Langenbeck's archives of surgery · 2005Review
- Nissen or partial posterior fundoplication: which antireflux procedure has a lower rate of side effects?Langenbeck's archives of surgery · 2005Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is caused by a mechanically defective lower esophageal sphincter (LES) and may be worsened by impaired esophageal peristalsis. The aim of this study was to evaluate the efficacy of medical treatment depending on the function of the LES and esophageal peristalsis. We studied 128 GERD patients with mild esophagitis. Group 1 (N = 26) consisted of patients with a normal LES and normal esophageal peristalsis. Group 2 (N = 63) comprised patients with a defective LES but normal peristalsis. Patients of group 3 (N = 39) had a defective LES as well as impaired esophageal peristalsis. The patients were continuously treated with omeprazole. Clinical evaluation and endoscopy were repeated after 3, 6, and 12 months. Recurrence of GERD was diagnosed if there was relapse of heartburn and/or esophagitis. The recurrence rate was 7.7% in group 1, 38.1% in group 2 (P < 0.05) and 79.5% in group 3 (P < 0.05). In conclusion, in GERD patients with a mechanically defective LES, especially in those with deteriorated esophageal peristalsis, antireflux surgery should be considered since medical therapy reveals a high recurrence rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.