ArticleAmerican journal of human genetics2003
Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- The human genome harbours widespread exclusive yin yang haplotypes.European journal of human genetics : EJHG · 2024Article
- Analysis of Common SNPs across Continents Reveals Major Genomic Differences between Human Populations.Genes · 2022Article
- Quinoa genome assembly employing genomic variation for guided scaffolding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants.Cell reports. Medicine · 2021Article
- Non-classical human leukocyte antigen class I in Tunisian children with autism.Central-European journal of immunology · 2020Article
- FTO haplotyping underlines high obesity risk for European populations.BMC medical genomics · 2019Article
- Intricacies in arrangement of SNP haplotypes suggest "Great Admixture" that created modern humans.BMC genomics · 2017Article
- Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes.G3 (Bethesda, Md.) · 2016Article
- Rare missense variants within a single gene form yin yang haplotypes.European journal of human genetics : EJHG · 2016Article
- To Cheat or Not To Cheat: Tryptophan Hydroxylase 2 SNP Variants Contribute to Dishonest Behavior.Frontiers in behavioral neuroscience · 2016Article
- Human gephyrin is encompassed within giant functional noncoding yin-yang sequences.Nature communications · 2015Article
- Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes.The HUGO journal · 2011Article
- The association between variants on chromosome 9p21 and inflammatory biomarkers in ethnically diverse women with coronary heart disease: a pilot study.Biological research for nursing · 2011Article
- The relationship between polymorphisms on chromosome 9p21 and age of onset of coronary heart disease in black and white women.Genetic testing and molecular biomarkers · 2011Article
- A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.European heart journal · 2011Article
- Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.Alcoholism, clinical and experimental research · 2011Article
- Haplotype block: a new type of forensic DNA markers.International journal of legal medicine · 2010Article
- APC Yin-Yang haplotype associated with colorectal cancer risk.Experimental and therapeutic medicine · 2010Article
- Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome.BMC genetics · 2010Article
- Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations.Heart Asia · 2010Article
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4 authors.
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Abstract
Knowledge of human haplotype structure has important implications for strategies of disease-gene mapping and for understanding human evolutionary history. Many attributes of SNPs and haplotypes appear to exhibit highly nonrandom behavior, suggesting past operation of selection or other nonneutral forces. We report the exceptional abundance of a particular haplotype pattern in which two high-frequency haplotypes have different alleles at every SNP site (hence the name "yin yang haplotypes"). Analysis of common haplotypes in 62 random genomic loci and 85 gene coding regions in humans shows that the proportion of the genome spanned by yin yang haplotypes is 75%-85%. Population data of 28 genomic loci in Drosophila melanogaster reveal a similar pattern. The high recurrence (>/=85%) of these haplotype patterns in four distinct human populations suggests that the yin yang haplotypes are likely to predate the African diaspora. The pattern initially appeared to suggest deep population splitting or maintenance of ancient lineages by selection; however, coalescent simulation reveals that the yin yang phenomenon can be explained by strictly neutral evolution in a well-mixed population.
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