ArticleMolecular and cellular biology2003
Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Spatiotemporal single-cell architecture of gene expression in the Caenorhabditis elegans germ cells.Cell discovery · 2025Article
- Condensin I folds the Caenorhabditis elegans genome.Nature genetics · 2024Article
- ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells.Nature structural & molecular biology · 2023Article
- Genetic analysis of Caenorhabditis elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline.Biology open · 2022Article
- PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.EMBO reports · 2020Article
- Meiosis.WormBook : the online review of C. elegans biology · 2017Review
- The Irr1/Scc3 protein implicated in chromosome segregation inCell division · 2017Article
- Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana.Frontiers in plant science · 2015Article
- Sisters unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.Genetics · 2014Article
- The roles of cohesins in mitosis, meiosis, and human health and disease.Methods in molecular biology (Clifton, N.J.) · 2014Review
- Meiotic development in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.PLoS biology · 2012Article
- HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.PLoS genetics · 2012Article
- Article
- Coordinating cohesion, co-orientation, and congression during meiosis: lessons from holocentric chromosomes.Genes & development · 2010Review
- Establishment of sister chromatid cohesion.Current biology : CB · 2009Review
- Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.Molecular biology of the cell · 2009Article
- Cohesin gene defects may impair sister chromatid alignment and genome stability in Arabidopsis thaliana.Chromosoma · 2009Article
- Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.The Journal of cell biology · 2009Article
- Cohesins: chromatin architects in chromosome segregation, control of gene expression and much more.Cellular and molecular life sciences : CMLS · 2009Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sister chromatid cohesion is fundamental for the faithful transmission of chromosomes during both meiosis and mitosis. Proteins involved in this process are highly conserved from yeasts to humans. In screenings for sterile animals with abnormal vulval morphology, mutations in the Caenorhabditis elegans evl-14 and scc-3 genes were isolated. Defects in cell divisions were observed in germ line as well as in vulval and somatic gonad lineages. Through positional cloning of these genes, we have shown that EVL-14 and SCC-3 are likely the only C. elegans homologs of the yeast sister chromatid cohesion proteins Pds5 and Scc3, respectively. Both evl-14 and scc-3 mutants displayed defects in the meiotic germ line. In evl-14 mutants, synaptonemal complexes (SCs) were detectable but more than the usual six DAPI (4',6'-diamidino-2-phenylindole)-positive structures were seen at diakinesis, suggesting that EVL-14/PDS-5 is important for the maintenance of sister chromatid cohesion in late prophase. In scc-3 mutant animals, normal SCs were not visible and approximately 24 DAPI-positive structures were seen at diakinesis, indicating that SCC-3 is necessary for sister chromatid cohesion. Immunostaining revealed that localization of REC-8, a homolog of the yeast meiotic cohesin subunit Rec8, to the chromosomes depends on the presence of SCC-3 but not that of EVL-14/PDS-5. scc-3 RNA interference (RNAi)-treated embryos were 100% lethal and displayed defects in cell divisions. evl-14 RNAi caused a range of phenotypes. These results indicate that EVL-14/PDS-5 and SCC-3 have functions in both mitosis and meiosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.