ArticleMolecular and cellular biology2003
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Species-specific alternative splicing of SP110 drives tuberculosis susceptibility in cattle.Veterinary research · 2025Article
- Role of carotenoids and retinoids during heart development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation.Journal of biomedical science · 2018Article
- Host transcription factor Speckled 110 kDa (Sp110), a nuclear body protein, is hijacked by hepatitis B virus protein X for viral persistence.The Journal of biological chemistry · 2017Article
- Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System.Journal of virology · 2016Article
- Molecular characterization of Sp110 gene in pigs.Molecular genetics and genomics : MGG · 2016Article
- Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies.Seminars in immunopathology · 2016Review
- Article
- Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.The Journal of biological chemistry · 2015Article
- Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity.Human molecular genetics · 2013Article
- PPARs and HCV-Related Hepatocarcinoma: A Mitochondrial Point of View.PPAR research · 2012Article
- The interaction between HCV and nuclear receptor-mediated pathways.Pharmacology & therapeutics · 2011Review
- Article
- Transcriptional regulation by HSV-1 induced HTRP via acetylation system.Virologica Sinica · 2010Article
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.The Journal of infectious diseases · 2010Article
- Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor.Cancer science · 2009Article
- Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.Journal of hepatology · 2008Article
- Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.Journal of virology · 2008Article
- Modulation of signaling pathways by RNA virus capsid proteins.Cellular signalling · 2008Review
- Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner.Oncogene · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) core protein (core) plays a significant role in the development of chronic liver diseases caused by HCV infection. We have discovered that the core sensitized all-trans-retinoic acid (ATRA)-induced cell death in MCF-7 cells. Activation of retinoic acid receptor alpha (RARalpha)-mediated transcription by the core was also seen in all the cell lines tested. By use of a yeast two-hybrid system, we identified Sp110b as a candidate for a core-interacting cellular factor. Although the function of Sp110b has remained unknown, we observed that Sp110b interacts with RARalpha and suppresses RARalpha-mediated transcription. These data suggest that Sp110b is a transcriptional cofactor negatively regulating RARalpha-mediated transcription. RNA interference-mediated reduction of endogenous Sp110b levels depressed the ability of the core to activate RARalpha-mediated transcription, suggesting an essential role for Sp110b in this pathway. The normal nuclear subcellular localization of Sp110b was altered by molecular interaction with the core to the cytoplasmic surface of the endoplasmic reticulum. This evidence suggests a model in which the core sequesters Sp110b from the nucleus and inactivates its corepressor function to activate RARalpha-mediated transcription. These findings likely describe a novel system in which a cytoplasmic viral protein regulates host cell transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.