ArticleMolecular and cellular biology2003
Regulation of alternative splicing by SRrp86 and its interacting proteins.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis.BMC genomics · 2007Pooled it
- Alternative Splicing, RNA Editing, and the Current Limits of Next Generation Sequencing.Genes · 2023Article
- The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.Nature communications · 2022Article
- Potential Links between YB-1 and Fatty Acid Synthesis in Clear Cell Renal Carcinoma.Medical research archives · 2020Article
- The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.RNA biology · 2017Article
- Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target.Journal of Cancer · 2017Review
- Interactions between RNA-binding proteins and P32 homologues in trypanosomes and human cells.Current genetics · 2016Article
- iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.BMC biology · 2015Article
- Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.G3 (Bethesda, Md.) · 2015Article
- Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.BioMed research international · 2015Article
- RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions.PloS one · 2013Article
- Molecular characterization and expression patterns of serine/arginine-rich specific kinase 3 (SPRK3) in porcine skeletal muscle.Molecular biology reports · 2011Article
- Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.Molecular cell · 2010Article
- TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation.Nucleic acids research · 2010Article
- The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Control of the papillomavirus early-to-late switch by differentially expressed SRp20.Journal of virology · 2009Article
- Regulation of cyclin D1 RNA stability by SNIP1.Cancer research · 2008Article
- Scaffold attachment factor B1 functions in development, growth, and reproduction.Molecular and cellular biology · 2005Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.